Benefits of using a microencapsulated vitamin D delivery system in women with polycystic ovary syndrome
Eur J Hosp Pharm. 2021 Dec 1;ejhpharm-2021-002967. doi: 10.1136/ejhpharm-2021-002967 Paywall
Vesselina Yanachkova 1, Radiana Staynova 2, Svetoslav Stoev 3, Emilia Naseva 4
Objective: To compare and assess the efficacy of two vitamin D delivery systems (oil-based and microencapsulated) on 25-hydroxy-vitamin D (25(OH)D) levels, body mass index (BMI) and insulin resistance (IR) in women with established polycystic ovary syndrome (PCOS) and vitamin D deficiency.
Materials and methods: A monocentric, retrospective study was conducted, using the data of 70 female patients, who visited the endocrinology department of the "Dr. Shterev" Hospital, Sofia, Bulgaria between May 2020 and September 2020. The patients were divided into two groups according to the type of vitamin D3 supplementation: either a microencapsulated liposomal form (n=35), or a conventional oil-based form (n=35). The following clinical measures were analysed and compared: BMI, serum levels of 25(OH)D, fasting plasma glucose levels, fasting immunoreactive insulin (IRI), homeostatic model assessment (HOMA) index, levels of antimullerian hormone (AMH) II generation, and testosterone. In all selected patients, these measurements were performed at baseline and 3 months after initiation of vitamin D supplementation.
Results: Significantly increased serum levels of 25(OH)D were observed in patients supplemented with the microencapsulated form of vitamin D3 in the third month from the beginning of therapy, compared with the control group (p=0.003). In the microencapsulated vitamin D group, there was a decrease in IRI serum levels (p=0.023), HOMA-IR (p=0.021), serum AMH (p=0.010) and testosterone levels (p=0.006). The fasting plasma glucose levels did not change significantly.
Conclusion: The results of our study show that the patients supplemented with a microencapsulated form of vitamin D3 achieved faster compensation of 25(OH)D levels, which in turn, under equal conditions, led to significant improvement in the metabolic profile, in particular insulin sensitivity.
Vitamin D Life pages with NANOEMULSION in title (15 as of Oct 2022)
This list is automatically updated
See also in Vitamin D Life
- Advances in Vitamin D emulsions, nanoparticles, etc. – Jan 2019
- Liposomal Vitamin D cocktail targets some lung cancers – June 2018
- Vitamin D encapsulated in gum arabic 4X more bioavailable (in rat test)- July 2020
- The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
- Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
- Vitamin D Emulsions - nano 2X better than coarse – Dec 2017
- Forms of Vitamin D category listing has
99 items along with related searches Nanoemulsion Vitamin D faster and better (paywall) – RCT Dec 2021Printer Friendly PDF this page! Follow this page for updates37004 visitors, last modified 31 Oct, 2022, This page is in the following categories (# of items in each category)