Bioavailability of Different Vitamin D Oral Supplements in Laboratory Animal Model.
Medicina (Kaunas). 2019 Jun 10;55(6). pii: E265. doi: 10.3390/medicina55060265.
Šimoliūnas E1, Rinkūnaitė I2, Bukelskienė Ž3, Bukelskienė V4.
Nanemulsion form has a longer half-life and has 24% more "area under the curve" than oil-based
Note: Vitamin D generated by the Sun/UV has an even longer half-life
- Vitamin D nanoemulsion corrected deficiency and improved bones in 1 week (high dose in rats) – Jan 2019
- Vitamin D encapsulated in gum arabic 4X more bioavailable (in rat test)- July 2020
- Vitamin D nanoemulsion etc. for fortification, pills, injections, topical and cancer – July 2019
- Bioavailability of nanoemulsion formulations of Vitamin D3 – Nov 2019
- Vitamin D Emulsions - nano 2X better than coarse – Dec 2017
- Nanoemulsion Vitamin D may be a substantially better form
- Inhaling Vitamin D nanoemulsion through nose gets lots more to the brain (mice) – July 2020
- Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017
- Vitamin D nanoemulsion, with comments on COVID-19 – June 2, 2020
- (Nanoemulsion Vitamin D may be a substantially better form includes the following comparison
| Biotech Pharmacal 50,000 IU | Micro D3 Nanoemulsion | |
| Average Cost per day for 10,000 IU | 4 cents | 8 cents |
| IU per serving | 50,000 IU = capsule | 2,000 IU = drop |
| Servings if want 10,000 IU avg. per day | 1 capsule per 5 days | 25 drops = 1 /4 teaspoon per 5 days |
| Shelf life | 1 year? | 6 months? |
| Form | gel-cap/powder | Liquid |
| Add to food/drink | Yes | possiblly |
| Apply to skin | No | perhaps |
| Gut-friendly | perhaps | probably |
| Ingredients might cause allergic reaction in small % of people | No reaction | perhaps |
| Availability to cell - better than bio-availability | standard | perhaps 2X more - due to small size or activation of Vitamin D Receptor |
Download the PDF from Vitamin D Life
Background and Objectives: The major cause of vitamin D deficiency is inadequate exposure to sunlight. It is difficult to supplement it with food because sufficient concentrations of vitamin D naturally occur only in a handful of food products. Thereby, deficiency of this vitamin is commonly corrected with oral supplements. Different supplement delivery systems for improved vitamin D stability and bioavailability are proposed. In this study, we compared efficiency of three vitamin D delivery systems: microencapsulated, micellized, and oil-based.
Materials and Methods: As a model in this medical testing, laboratory rats were used for the evaluation of bioavailability of different vitamin D vehicles. Animals were divided into three groups: the first one was given microencapsulated vitamin D3, the second-oil-based vitamin D3, and the third-micellized vitamin D3. Test substances were given per os to each animal for 7 days, and vitamin D concentration in a form of 25-hydroxyvitamin D (25(OH)D) in the blood was checked both during the vitamin delivery period and later, up to the 24th day.
Results: Comparison of all three tested products showed that the microencapsulated and oil-based vitamin D3 vehicles were the most bioavailable in comparison to micellized vitamin D3. Even more, the effect of the microencapsulated form of vitamin D3 remained constant for the longest period (up to 14 days).
Conclusions: The results of this study suggest that the oral vitamin D supplement vehicle has an impact on its bioavailability, thus it is important to take into account how much of the suppled vitamin D will be absorbed. To maximize the full exploit of supplement, the best delivery strategy should be employed. In our study, the microencapsulated form of vitamin D was the most bioavailable.