A genetic insight into vitamin D binding protein and COVID-19
Medical Hypotheses; Volume 149, April 2021,https://doi.org/10.1016/j.mehy.2021.11053
lMona Alshahawey
Items in both categories Vitamin D binding Protein and virus:
- COVID-19 severity associated with 3 vitamin D genes – Oct 2021
- SARS-CoV-2 virus alters the activation of over 100 vitamin D related genes in the lung – April 2021
- Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021
- Another gene which limits Vitamin D is found to increase COViD-19 (Binding Protein in this case) Aug 8, 2020
- Meningitis and other brain infections should be prevented by Vitamin D – June 2014
Vitamin D Binding Protein category listing has 149 items and the following introductionVitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Vitamin D Binding Protein has a list of health problems
Increased
Risk Health Problem 11 X Preeclampsia 6 X Food Allergy 5 X PTSD 4 X, 5X Kidney Cancer 4 X Poor Response to Oral Vitamin D 3 X Ear infection 2 X MS 2 X Colorectal Cancer 2 X Prostate Cancer -in those with dark skins 1.3 X Infertility
Genetics category contains the following
285 articles in the Genetics category see also
426 articles in Vitamin D Receptor149 articles in Vitamin D Binding Protein = GC40 articles in CYP27B1- CYP24A1 in title (27 as of Dec 2021)
- Calcitriol category listing has
54 items- Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- CYP3A4
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
 Download the PDF from Vitamin D Life
It’s since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A “pandemic”; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes [1]. As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I’d believe that vitamin D binding protein (DBP) is maybe also involved. A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.
Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021 577 visitors, last modified 07 Mar, 2021,
Printer Friendly PDF this page! Follow this page for updates This page is in the following categories (# of items in each category)
Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,
- GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
- The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
- The actual D getting to the cells is a function of measured D and all 4 genes
- There is >2X increase in 8+ health problems if have poor VDBP (GC)
- It appears that VDBP only blocks oral vitamin D,
- but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
- A clue: - Vitamin D from UV is 2X better for MS than oral UV
Vitamin D Binding Protein has a list of health problems
Increased Risk | Health Problem |
11 X | Preeclampsia |
6 X | Food Allergy |
5 X | PTSD |
4 X, 5X | Kidney Cancer |
4 X | Poor Response to Oral Vitamin D |
3 X | Ear infection |
2 X | MS |
2 X | Colorectal Cancer |
2 X | Prostate Cancer -in those with dark skins |
1.3 X | Infertility |
Genetics category contains the following
see also
426 articles in Vitamin D Receptor 149 articles in Vitamin D Binding Protein = GC 40 articles in CYP27B1 - CYP24A1 in title (27 as of Dec 2021)
- Calcitriol category listing has
54 items - Topical Vitamin D
- Nanoemulsion Vitamin D may be a substantially better form
- CYP3A4
- Getting Vitamin D into your body
Vitamin D blood test misses a lot
- Snapshot of the literature by Vitamin D Life as of early 2019
- Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
- Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
- A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
- Commercially available 2019
- However test results would vary in each tissue due to multiple genes
- Good clues that Vitamin D is being restricted from getting to the cells
1) A vitamin D-related health problem runs in the family- especially if it is one of 51+ diseases related to Vitamin D Receptor
2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016- easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
4) Back Pain- probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
- The founder of Vitamin D Life took action with clues #3&4
 Download the PDF from Vitamin D Life
It’s since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A “pandemic”; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes [1]. As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2], I’d believe that vitamin D binding protein (DBP) is maybe also involved. A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.
Hypothesis: Poor Vitamin D Binding protein may increase COVID-19 risk - March 6, 2021577 visitors, last modified 07 Mar, 2021, This page is in the following categories (# of items in each category)