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Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021

Diagnostic Aspects of Vitamin D: Clinical Utility of Vitamin D Metabolite Profiling

JMBR https://doi.org/10.1002/jbm4.10581
Glenville Jones,Martin Kaufmann

2021

Ratio of metabolites provides an interesting view
Image

The assay of vitamin D that began in the 1970s with the quantification of one or two metabolites, 25-OH-D or 1,25-(OH)2D, continues to evolve with the emergence of liquid chromatography tandem mass spectrometry (LC-MS/MS) as the technique of choice. This highly accurate, specific, and sensitive technique has been adopted by many fields of endocrinology for the measurement of multiple other components of the metabolome, and its advantage is that it not only makes it feasible to assay 25-OH-D or 1,25-(OH)2D but also other circulating vitamin D metabolites in the vitamin D metabolome. In the process, this broadens the spectrum of vitamin D metabolites, which the clinician can use to evaluate the many complex genetic and acquired diseases of calcium and phosphate homeostasis involving vitamin D. Several examples are provided in this review that additional metabolites (eg, 24,25-(OH)2D3, 25-OH-D3-26,23-lactone, and 1,24,25-(OH)3D3) or their ratios with the main forms offer valuable additional diagnostic information. This approach illustrates that biomarkers of disease can also include metabolites devoid of biological activity. Herein, a case is presented that the decision to switch to a LC-MS/MS technology permits the measurement of a larger number of vitamin D metabolites simultaneously and does not need to lead to a dramatic increase in cost or complexity because the technique uses a highly versatile tandem mass spectrometer with plenty of reserve analytical capacity. Physicians are encouraged to consider adding this rapidly evolving technique aimed at evaluating the wider vitamin D metabolome toward streamlining their approach to calcium– and phosphate-related disease states.
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Vitamin D Life - CYP27B1 category listing contains the following

The CYP27B1 gene activates Vitamin D in the Kidney,    Skin,    Lungs,    Brain,   Eyes   Breasts   etc.
CYtochrome P450 family 27 subfamily B member 1    = 25-Hydroxyvitamin D3 1-alpha-hydroxylase

Vitamin D blood test misses CYP27B1 and other genes
Blood Test Misses a lot (VDW 3439)

Vitamin D Life pages with CYP24A1 in title (27 as of Dec 2021)

This list is automatically updated

Items found: 27
Title Modified
Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021 08 Dec, 2021
3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012 22 Jan, 2021
Hypertension 2X more likely if poor CYP24A1 vitamin D gene (China) – Jan 2020 10 Jan, 2020
Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019 18 Nov, 2019
Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D) – Nov 2019 16 Nov, 2019
Prostate Cancer associated with various genes, including Vitamin D Receptor and CYP24A1 – Nov 2019 15 Nov, 2019
Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019 15 Nov, 2019
Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case) – Nov 2019 07 Nov, 2019
CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012 16 May, 2019
Hepatitis C 1.4X more likely if poor CYP24A1 gene – May 2019 08 May, 2019
Natural pregnancy 4X more likely if sperm had a lot of CYP24A1 – April 2019 10 Apr, 2019
Vitamin D accumulation in 1 in 300 people due to gene (CYP24A1) can cause Calcium problems – June 2018 31 Dec, 2018
CYP24A1 gene mutation is a cause of rare infant vitamin D toxicity – Aug 2011 31 Dec, 2018
CYP24A1 enzyme and Vitamin D 31 Dec, 2018
CYP24A1 enzyme and Vitamin D 31 Dec, 2018
Maternal diabetes with poor Vitamin D gene (CYP24A1) increases risk of diabetes in female offspring by 40 percent – Jan 2018 24 Jan, 2018
Vitamin D gene (CYP24A1) changes decrease breast and pancreatic cancers – meta-analysis Nov 2017 20 Dec, 2017
Calcium problems associated with CYP24A1 (a Vitamin D gene) – Oct 2017 08 Nov, 2017
If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016 07 Jun, 2017
Rare mutation of gene (CYP24A1) results in Vitamin D accumulating in the body – Jan 2017 23 Jan, 2017
Breast Cancer rate reduced 72 percent by vitamin D gene polymorphism CYP24A1 – Nov 2014 30 Mar, 2016
Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015 16 Nov, 2015
Genes such as CYP27B1, CYP24A1 and Vitamin D – JAMA Nov 2012 16 Nov, 2015
Mutations in CYP24A1 gene (vitamin D) associated with kidney problems – Jan 2013 16 Nov, 2015
Activation (methylation) of CYP2R1 and CYP24A1 predict response to dose of vitamin D – Oct 2013 24 Feb, 2015
Breast cancer and Vitamin D receptors, CP27B1, and CYP24A1 – Sept 2010 26 Nov, 2014
CYP24A1 gene, kidney disease, and vitamin D - May 2011 02 Nov, 2012
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Vitamin D Metabolite Profiling and genes (CYP24A1, CYP27B1)– Nov 2021        
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