Combating COVID-19 and Building Immune Resilience: A Potential Role for Magnesium Nutrition?
J Am Coll Nutr. 2020 Jul 10;1-9. doi: 10.1080/07315724.2020.1785971
Taylor C Wallace 1 2 3
Magnesium and Vitamin D contains the following highlights
- Overview Magnesium and vitamin D
- Magnesium deficiency – causes and symptoms – May 2016
- Vitamins and Metals needed by the Immune System – Jan 2020
- Magnesium deficiency estimated by just 6 Yes No questions - Dec 2019
- Magnesium etc. reduced in crops (must supplement) – 2009
- The Importance of Magnesium in Clinical Healthcare (with level of evidence) – Sept 2017
- Magnesium is great for health, topical much faster than oral, MgCl is the best – 2019
- Magnesium is important for health but levels are low – July 2018
- 500 mg of Magnesium for 8 weeks increased Vitamin D about 30 pcnt – RCT July 2020
- Dr. Coimbra interview covering Vitamin D, Magnesium, Folate, Vaccines - Oct 2018
- How to get lots of Magnesium – especially needed for Coimbra MS and Autoimmune Protocol
Mg and Vitamin D
- Why Vitamin D is Useless without This Critical Nutrient (Magnesium) - Jan 2019
- Magnesium supplementation raises Vitamin D if initially less than 30 ng – RCT Dec 2018
- Magnesium is vital to Vitamin D in 4 places (maybe 8) – March 2018
- Magnesium and Vitamin D – recent deficiencies, needed, synergistic - good overview 2017
- Vitamin D Cofactors in a nutshell
- Magnesium and Vitamin D - similar, different and synergistic
- Some Podcasts by Dr. C Dean – Magnesium, Vitamin D, Iodine, etc.
- Magnesium and the body - depletion and reduced intake - Dean Oct 2019
- Magnesium, Vitamin D, Omega-3, TSH - importance and testing - Dean and Baggerly - Oct 2019
Number of studies in both of the categories of Magnesium and:Bone
Download the PDF from Vitamin D Life
Background: In December 2019, the viral pandemic of respiratory illness caused by COVID-19 began sweeping its way across the globe. Several aspects of this infectious disease mimic metabolic events shown to occur during latent subclinical magnesium deficiency. Hypomagnesemia is a relatively common clinical occurrence that often goes unrecognized since magnesium levels are rarely monitored in the clinical setting. Magnesium is the second most abundant intracellular cation after potassium. It is involved in >600 enzymatic reactions in the body, including those contributing to the exaggerated immune and inflammatory responses exhibited by COVID-19 patients.
Methods: A summary of experimental findings and knowledge of the biochemical role magnesium may play in the pathogenesis of COVID-19 is presented in this perspective. The National Academy of Medicine's Standards for Systematic Reviews were independently employed to identify clinical and prospective cohort studies assessing the relationship of magnesium with interleukin-6, a prominent drug target for treating COVID-19.
Results: Clinical recommendations are given for prevention and treatment of COVID-19. Constant monitoring of ionized magnesium status with subsequent repletion, when appropriate, may be an effective strategy to influence disease contraction and progression. The peer-reviewed literature supports that several aspects of magnesium nutrition warrant clinical consideration. Mechanisms include
- its "calcium-channel blocking" effects that lead to downstream suppression of nuclear factor-Kβ, interleukin-6, c-reactive protein, and other related endocrine disrupters;
- its role in regulating renal potassium loss; and
- its ability to activate and enhance the functionality of vitamin D, among others.
Conclusion: As the world awaits an effective vaccine, nutrition plays an important and safe role in helping mitigate patient morbidity and mortality. Our group is working with the Academy of Nutrition and Dietetics to collect patient-level data from intensive care units across the United States to better understand nutrition care practices that lead to better outcomes.
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