Vitamin D and morbidity in children with multisystem inflammatory syndrome related to Covid-19?
Progress in Pediatric Cardiology. 1 March 2022, https://doi.org/10.1016/j.ppedcard.2022.101507
DianaTorpoco-RiveraaAmritMisraaYamunaSanilaNatalieSabzghabaeibRayaSafaacRichard U.Garciaac
Background
Multisystem inflammatory syndrome (MIS-C) is a clinical presentation reported in children related to Coronavirus-19 infection who present with a toxic shock like syndrome. Vitamin D deficiency has been postulated to play a role with severity of coronavirus infection in adult patients and other viral respiratory infections.
Objective
This study aims to investigate if severe vitamin D deficiency was associated with increased disease severity and cardiac involvement in MIS-C.
Methods
This is a retrospective and single center study. We included hospitalized patients less than 18 years of age with diagnosis of MIS-C between March and July 2020. Severe vitamin D deficiency was defined as 25-OH vitamin D level < 10 ng/ml within 48 h of admission. The composite outcome severe disease included patients requiring inotropes, mechanical ventilation, and extracorporeal membrane oxygenation.
Results
Of the 31 patients with MIS-C, 45% were male and 58% were African American. The median age was 8 (1–13) years. Ten patients had severe vitamin D deficiency with a mean level of 7.2 ng/ml. Ninety percent of patients with severe vitamin D deficiency had severe disease (P < 0.001). Patients with severe vitamin D deficiency had an increased risk of cardiac involvement (P < 0.001).
Conclusions
We describe a potential association between severe vitamin D deficiency and severe disease in children presenting with MIS-C. Severe vitamin D deficiency predisposes patients for cardiovascular involvement and, may play a critical role in the host immune response to COVID-19 infection. Future prospective studies at the basic science and clinical level should be pursued to better delineate this association.
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Multisystem inflammatory syndrome in children (MIS-C) related to COVID-19 infection in the state of Qatar: Association with Kawasaki-like Illness - Jan 2022
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Vitamin D Life
- Hospitalized children with COVID-19 and inflammation had lower vitamin D – March 2021
- 8 of 10 pediatric COVID-19 infections were Vitamin D deficient (49 patients) – May 2021
Vitamin D Life studies in Children + Inflammation + Virus
This list is automatically updated
- COVID children with multisystem inflammatory syndrome have less than 10 ng of vitamin D – March 2022
- 8 of 10 pediatric COVID-19 infections were Vitamin D deficient (49 patients) – May 2021
- Hospitalized children with COVID-19 and inflammation had lower vitamin D – March 2021
- Vitamin D might reduce Multisystem Inflammatory Syndrome in children – March 2021