Vitamin D Supplementation Seems to Improve Fibromyalgia Symptoms: Preliminary Results.
Isr Med Assoc J. 2018 Jun;20(6):379-381. PMID: 29911760
de Carvalho JF, da Rocha Araújo FAG, da Mota LMA, Aires RB, de Araujo RP.
Visual analog scale scores (out ot 100)
90 Before
30 After
See also Vitamin D Life
- Overview Fibromyalgia or Chronic Fatigue and vitamin D - which is the most-read page on Vitamin D Life
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
Items in both categories Chronic Pain and Intervention are listed here:
- Several Diabetic pains reduced by injection of 300,000 IU of Vitamin D – RCT Feb 2020
- Dysmenorrhea substantially reduced by Ginger, just 1,000 IU Vitamin D also helped – RCT Nov 2019
- Rheumatoid Arthritis pain reduced by monthly 100,000 IU of Vitamin D – Oct 2018
- Fibromyalgia pain substantially reduced by weekly Vitamin D (50,000 IU) – June 2018
- 100,000 IU of vitamin D monthly decreases use of NASIDs by 13 percent if low vitamin D – RCT May 2018
- Fatigue reduced by a single dose of vitamin D (100,000 IU) – RCT Dec 2016
- Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
- Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
- High dose vitamin reduced pain of fibromyalgia, osteoarthritis, and rheumatoid arthritis - July 2015
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- Growing pains reduced 57 percent by vitamin D therapy – May 2015
- Pain of Diabetic Neuropathy reduced with weekly 50,000 IU vitamin D– CT Feb 2015
- Musculoskeletal pain reduced with 4,000 IU of vitamin D – RCT April 2015
- Pain reduced when enough vitamin D was given – review March 2015
- Less use of musculoskeletal pain drugs if get vitamin D – Feb 2015
- Angina dramatically reduced by injections of vitamin D twice a month (300,000 IU) – Jan 2015
- Growing pains reduced 60 percent by monthly Vitamin D – March 2014
- Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014
- 400,000 IU of vitamin D reduced adult pain and improved quality of life – March 2014
- Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014
- Quality of Life
- Vitamin D injections of a total of 1,800,000 IU reduced shinbone tenderness – Feb 2013
- 150,000 IU vitamin D reduced pain in immigrants – RCT Dec 2012
- Breast Cancer medicine pain reduced with 4300 IU vitamin D – RCT June 2012
- 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
- Menstrual Pain reduced by vitamin D – RCT 2012, 2014, 2016
- Raynaud's pain decreased with 600,000 IU monthly vitamin D – RCT May 2012
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BACKGROUND:
Vitamin D deficiency and insufficiency have been reported in fibromyalgia. However, to the best of our knowledge, only one study has evaluated the role of 25-hydroxyvitamin D [25(OH)D] supplementation on fibromyalgia symptoms.
OBJECTIVES:
To analyze the effects of 3 months of 25(OH)D supplementation on symptoms of fibromyalgia.
METHODS:
This study included 11 female patient. Demographic and clinical data, tender points, visual analog scale results, and pre- and post-serum levels of 25(OH)D supplementation were analyzed. The levels of 25(OH)D were measured by a radioimmunologic test.
RESULTS:
Patients with fibromyalgia diagnosis and 25(OH)D values ≤ 30 ng/ml were recruited to receive 50,000 IU of oral vitamin D once every week for 3 months. The disease was diagnosed based on the American College of Rheumatology criteria. The median age of all patients was 48.5 (28-67) years and 63.4% were Caucasian. Disease duration varied from 1-10 years. The 25(OH)D levels increased significantly after 3 months, 18.4 (15.5-25.8) ng/ml vs. 33.8 (28-58) ng/ml, P = 0.01. Interestingly, an improvement of visual analog scale scores was observed at 3 months, 90 (0-100) vs. 30 (0-80), P = 0.002.
Eight patients (72.2%) responded that they experienced a very significant improvement in symptoms. In addition, a trend for reduction of the number of tender points was observed after 3 months, 17 (11-18) vs. 10 (0-18), P = 0.07.
CONCLUSIONS:
The 25(OH)D levels and disease symptoms in patients with fibromyalgia and vitamin D deficiency/insufficiency seem to improve with vitamin D supplementation.