Do You Believe the Myth That You Can't Prevent Alzheimer's – Mercola, Aug 2017

Update: Interview of Dr. Bredesen by Dr. R Patrick Oct 2018

extensive data, hyperlinks, highlights

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ReCODE: The Reversal of Cognitive Decline

Story at-a-glance

• Dr. Dale Bredesen’s ReCODE protocol evaluates 150 factors known to contribute to Alzheimer’s disease. This identifies your disease subtype or combination of subtypes, and an effective treatment protocol can be devised
• Type 1 Alzheimer’s is primarily caused by inflammatory factors; type 2 involves atrophic responses; type 1.5 is a mix of inflammation and atrophy, and type 3 is primarily caused by toxic exposures
• Only 5 percent of Alzheimer’s cases are “familial” Alzheimer’s disease, a genetic condition that causes early onset Alzheimer’s; the rest are caused by lifestyle factors over which we have a great deal of control; hence, we have the ability to improve or even reverse most cases of the disease

Includes interview and transcript of Dr. Bredesen, author
The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline Amazon, Aug 2017 $14 Kindle

4 Alzheimer’s Subtypes

While these classifications have not become widely accepted yet, Bredesen has published two papers on Alzheimer’s subtypes, based on metabolic profiling.4 These include:

• 1. Type 1, inflammatory (“hot”) Alzheimer’s: Patients present predominantly inflammatory symptoms. They have high-sensitivity C-reactive protein, interleukin 6 and tumor necrosis factor alpha, reflecting a chronic inflammatory state. When the NF-ĸB part of inflammation is activated, it also alters gene transcription. Two of the genes turned “on” are beta-secretase and gamma-secretase, the latter of which cleaves APP, thereby promoting synaptoclastic processes.
• 2. Type 1.5, glycotoxic (sugar-toxic, “sweet, a mixed subtype: This is an in-between subtype that involves both inflammation and atrophy processes, due to insulin resistance and glucose-induced inflammation.
• 3. Type 2, atrophic or “cold”Alzheimer’s: This is classified as patients presenting an atrophic response. While a completely different mechanism from inflammation, it produces the same end result — it pushes APP in the direction of creating amyloid plaques and Alzheimer’s cell signaling.
• 4. Type 3, toxic (“vile”) Alzheimer’s: These are patients with toxic exposures. Many will have chronic inflammatory response syndrome (CIRS) markers, even though most do not fit the official criteria for CIRS. “They act like CIRS patients (in their labs, not necessarily symptoms) with dementia,” Bredesen explains.

Sections of the article include

• If You’re ApoE4 Positive, Fasting Is Strongly Indicated to Avoid Alzheimer’s
• Mitochondrial Dysfunction Is at the Heart of Alzheimer’s
• The ReCODE protocol evaluates 150 different variables, including biochemistry, genetics and historical imaging, to determine which factors are most likely driving the disease.

Alzheimer’s Screening Tests

Test	Recommended range
Ferritin	40 to 60 ng/mL
GGT	<16 U/L for men and < 9 U/L for women
25-hydroxy vitamin D	40 to 60 ng/mL
High-sensitivity CRP	<0.9 mg/L
Fasting Insulin	< 4.5 mg/dL
Omega-3 index and Omega 6:3 ratio	Omega-3 index > 8 %
TNF alpha	< 6.0
TSH	Less than 2.0 microunits/mL
Free T3	3.2-4.2 pg/mL
Reverse T3	<20 ng/mL
Free T4	1.3-1.8 ng/mL
Serum copper and zinc ratio	0.8-1.2
Serum selenium	110-150 ng/mL
Glutathione	5.0-5.5 μm
Vitamin E (alpha tocopherol)	12-20 mcg/mL
Body mass index	18-25
ApoE4 (DNA test)	See how many alleles you have: 0, 1 or 2
Vitamin B12	500-1,500
Hemoglobin A1c	Less than 5.5
Homocysteine	4.4-10.8 mcmol/L

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See also Vitamin D Life

• Schizophrenia increased 40 percent for Spring births after Danes stopped vitamin D fortification – April 2014
• Vitamin D reduces Alzheimer’s disease in at least 11 ways – Jan 2013
• Genes which reduce blood-level vitamin D increase the risk of Alzheimer’s disease – Dec 2016
• Alzheimer plaque possibly cleared by Vitamin D – Nov 2017
• Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• Alzheimer’s (apoE4) may require more than Omega-3 - May 2017
• Cognitive Impairment 1.8 times more likely if low Omega-3– Oct 2016
• Schizophrenia relapses reduced 3X by Omega-3 – RCT Mar 2015
• Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015
• Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

290 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search Vitamin D Life for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search Vitamin D Life for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014

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See also web

• The 3 Vitamins that Prevent Brain Loss Aug 2017
  "Our body can detoxify homocysteine, though, using three vitamins: folate, vitamin B12, and vitamin B6"
  " B-vitamin treatment reduces, by as much as seven-fold] the brain atrophy in the regions specifically vulnerable to the Alzheimer’s disease process."
  •  Download the PDF of Alz and B Vitamins study from Vitamin D Life

Dale E. Bredesen as author or co-author

• Transcriptional Effects of ApoE4: Relevance to Alzheimer's Disease June 2018
• Ayurvedic Profiling of Alzheimer's Disease May 2017 PMID 28236613
• Reversal of cognitive decline in Alzheimer's disease June 2016
  •  Download the PDF from Vitamin D Life
• Inhalational Alzheimer's disease: an unrecognized - and treatable - epidemic - 2016
  •  Download the PDF from Vitamin D Life