Vitamin D levels change Gut Microbiota – 25 study review Sept 2021

The Association between Vitamin D and Gut Microbiota: A Systematic Review of Human Studies

Nutrients 2021, 13(10), 3378; https://doi.org/10.3390/nu13103378
by Federica Bellerba 1,†,Valeria Muzio 2,†,Patrizia Gnagnarella 2,*OrcID,Federica Facciotti 1OrcID,Susanna Chiocca 1OrcID,Paolo Bossi 3OrcID,Diego Cortinovis 4OrcID,Ferdinando Chiaradonna 5OrcID,Davide Serrano 6OrcID,Sara Raimondi 1,Barbara Zerbato 5,Roberta Palorini 5,Stefania Canova 4,Aurora Gaeta 1 andSara Gandini 1OrcID

(This article belongs to the Special Issue Current Understanding of Vitamin D in
Chronic Diseases, Acute Respiratory Infections and All-Cause Mortality) 6 papers as of Sept 26, 2021 - which includes

• Vitamin D Level Trajectories of Adolescent Patients with Anorexia Nervosa at Inpatient Admission, during Treatment, and at One Year Follow Up: Association with Depressive Symptoms
• Vitamin D Supplementation and Disease-Free Survival in Stage II Melanoma: A Randomized Placebo Controlled Trial
  • See Vitamin D Life Melanoma not treated by small doses of vitamin D (100,000 IU every 50 days) – RCT June 2021
• Association of Vitamin D Receptor and Vitamin D-Binding Protein Polymorphisms with Familial Breast Cancer Prognosis in a Mono-Institutional Cohort
• Microbiome as Mediator of Diet on Colorectal Cancer Risk: The Role of Vitamin D, Markers of Inflammation and Adipokines
• Vitamin D Receptor (VDR) Gene Polymorphism in Patients Diagnosed with Colorectal Cancer
  • In Vitamin D Life Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021

Recent evidence has shown a number of extra-skeletal functions of Vitamin D (VD), primarily involving the immune system. One of these functions is mediated by the modulation of gut microbiota, whose alterations are linked to many diseases. Our purpose is to contribute to the understanding of existing evidence on the association between VD and gastrointestinal microbiota alterations. A systematic review of studies with human subjects has been conducted up to January 2021. We included publications reporting the association between gut microbiota and VD, including VD supplementation, dietary VD intake and/or level of 25(OH)D.
We identified 25 studies: 14 were interventional and 11, observational. VD supplementation was found to be associated with a significant change in microbiome composition, in particular of Firmicutes, Actinobacteria and Bacteroidetes phyla. Furthermore, Firmicutes were found to be correlated with serum VD. Concerning alpha and beta diversity, a high nutritional intake of VD seems to induce a shift in bacterial composition and/or affects the species’ richness. Veillonellaceae and Oscillospiraceae families, in the Firmicutes phylum, more frequently decreased with both increasing levels of 25(OH)D and vitamin D supplementation. We found evidence of an association, even though the studies are substantially heterogeneous and have some limitations, resulting sometimes in conflicting results. To further understand the role of VD on the modulation of the gastrointestinal microbiota, future research should be geared toward well-designed animal-based studies or larger randomized controlled trials (RCTs).
 Download the PDF from Vitamin D Life

The articles in both of the categories Microbiome and Gut:

How Your Microbiome Affects Your Emotions and Wellbeing - GrassrootsHealth Sept 2021

Short article and 7 min. video

A few related items in Vitamin D Life that you might find interesting

• Healthy microbiota might reduce COVID-19 – multiple studies
• Poor absorption of Vitamin D is strongly related to type of gut bacteria – Dec 2020
• Vitamin D and the Host-Gut Microbiome: A Brief Overview– June 2020

Antibiotics, probiotics starts with