Vitamin D and cancer – epidemiological association with colon and breast – Sept 2014

Vitamin D and Cancer: An overview on Epidemiological studies

Advances in Experimental Medicine and Biology 810:17-32 · September 2014
José Manuel Ordóñez Mena1,2 and Hermann Brenner1,3
1 Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany.E-Mail: 2 jose.ordonezmena at dkfz.de ; 3 hermann.brenner at dkfz.de

In recent years, a rapidly increasing number of studies have investigated the relationship of vitamin D with total cancer and site-specific cancer obtaining diverse findings. In this chapter we provide an overview of epidemiological studies of vitamin D intake, 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D serum levels and vitamin D associated polymorphisms in relation to total and site-specific cancer risk. Overall, epidemiological evidence for total cancer is inconclusive.
However, a large number of studies support a relationship of vitamin D with colorectal cancer and to a lesser extent with breast cancer. Findings are inconsistent for other cancers including all other gastrointestinal cancers and prostate cancer.
Different vitamin D associated polymorphisms were found to be significantly associated to colorectal, breast and prostate cancer risk.

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See also Vitamin D Life

Overview Cancer-Colon and vitamin D
Overview Breast Cancer and Vitamin D contains the following summary and sections

• 16+ meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 223 items along with related searches

Cancer category starts with the following

• Cancer 211 items Overview Cancer and vitamin D
• After Cancer Diagnosis 84 items
• Bladder Cancer 25 items
• Breast Cancer 223 items Overview Breast Cancer and Vitamin D
• Colon Cancer 116 items Overview Cancer-Colon and vitamin D
• Leukemia 16 items
• Liver Cancer 14 items
• Lung Cancer 49 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 22 items
• Other Cancer 55 items
• Ovarian Cancer 21 items
• Pancreatic Cancer 55 items
• Prostate Cancer 92 items Prostate Cancer and Vitamin D studies
• Skin Cancer 110 items Overview Suntans melanoma and vitamin D
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Breast Cancer Mortality reduced 60 percent if more than 60 ng of Vitamin D – meta-analysis June 2017
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Pancreatic cancer 55 percent less likely if optimal vitamin D (vs low) – Nov 2017
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Cancer is leading cause of death - Vitamin D and Receptor activators help
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 15 articles
• Breast Cancer and VDR 15 articles
• Colon Cancer and VDR 9 articles
• Prostate Cancer and VDR 6 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves by actively reducing Receptor activation