Topical Vitamin D provides more benefits than oral for some people

It appears that ~10% of people will benefit from Topical more than the Oral form of Vitamin D
It appears that ~20% of people having specific health problems will get more benefit from Topical than Oral

• Preeclampsia. Food Allergy, PTSD, Ear infection, Infertility, MS, Colon Cancer, TB, Asthma, COPD, Epilepsy, Atrial Fibrillation. Liver
• Also suspect for those people with poor guts: Cystic Fibrosis, Diabetes

However, Topical formsof Vitamin D are:

• 10X-100X more expensive
• Harder to use than oral for most people
• Do not easily allow high doses - for loading doses or non daily dosing (biweekly etc)
  • Vitamin D cream might be OK - 5 squirts of cream = 50,000 IU

Most body tissues can fully activate Vitamin D locally (without the Liver and Kidneys)
   Tissues such as the skin, the inside of the cheeks, the lungs, and the nose
Some people have a poor vitamin D binding gene

• Limits the amount of semi-activated Vitamin D from the liver
• The vitamin D binding gene does not appear to limit vitamin D that is activated by tissue

An increasing number of people have poor Vitamin D genes

• Starting in the 1930's people with poor immune systems have been surviving due to better hygiene, antibiotics, vaccines, etc.
• Since then, poor immune system genes have more frequently been passed on to future generations
• Before there was "Survival of the Fittest", but there is "Survival of the Survivors"

Many reasons why vitamin D deficiency has become epidemic includes the following chart

Topical Vitamin D sources include:

• Sun
• UV - sunbed or make UV lamp at home
• Topical Vitamin D oil
• Topical Vitamin D cream Amazon 10.000 IU   Amazon 15,000 IU
• Topical Vitamin D water (open up and dissolve 50,000 IU powder in 1/2 tsp of water)
  • Keep Vitamin D water under tongue for a few minutes
  • Apply Vitamin D water to skin
• Spray inside of the cheek or on the skin Amazon 100+ companies Oct 2019
• Vitamin D patches Amazon, 5,000 IU in 8 hours
• Inhaled Vitamin D - make at home

Note: Topical Vitamin D may also be BETTER than most oral forms if you:

• Have Gut problems
• Dislike swallowing pills
• Have a low/poor blood level response to vitamin D supplementation- e.g., poor CYP27A1 gene (in your liver)
• Have poor Vitamin D Binding Protein (in your blood)

Vitamin D Binding Protein category in Vitamin D Life has 140 items and starts with:

Vitamin D Binding Protein (GC) gene can decrease the bio-available Vitamin D that can get to cells,

• GC is not the only such gene - there are 3 others, all invisible to standard Vitamin D tests
• The bio-available calculation does not notice the effect of GC, CYP27B1, CYP24A1, and VDR
• The actual D getting to the cells is a function of measured D and all 4 genes
• There is >2X increase in 8+ health problems if have poor VDBP (GC)
• It appears that VDBP only blocks oral vitamin D,
  • but NOT Vitamin D from sun, UV, topical or inhaled (tissue activated)
  • A clue: - Vitamin D from UV is 2X better for MS than oral UV

Vitamin D Binding Protein list of health problems includes:
   Preeclampsia, Food Allergy, PTSD, Poor Response to Oral Vitamin D, Ear infection, Multiple Sclerosis, Colorectal Cancer, Prostate Cancer - blacks,
   Infertility. TB, Asthma, COPD, Epilepsy, Atrial Fibrilation, and Obesity

Getting Vitamin D into your body shows all of the  sources

3 Reasons why you have not heard that Vitamin D is good for the skin:

1) Vitamin D has been patented to help the skin - and companies do not want to pay royalties

• WO/2006/133829 USE OF 25-HYDROXY-VITAMIN D3 - cream for many skin problems
• (WO/2006/094064) Sept 2006 METHOD OF REDUCING SCARS WITH VITAMIN D
• WO/2011/019617 VITAMIN D3 AND ANALOGS THEREOF FOR TREATING ALOPECIA - delivered to the skin March 2011
• Who said vitamin D could not be patented - Vitamin D Life
  • A patent is one of the 22 Criteria to associate a health problem with low vitamin D in Vitamin D Life

2) FDA requires a LOT of data to allow a claim that a supplement can improve health

It appears to cost >$30,000 to prepare, present, and defend a single health claim for a supplement

• FDA allows the claim that Vitamin D “supports healthy pregnancies and promotes full-term births” – Oct 2019
• FDA now allows specific Omega-3 health claims (Vitamin D claims are feasible) July 2019

3) Only recently have Vitamin D doses been large enough to really help (400X)