Some measures of metabolic syndrome are decreased by Vitamin D (may need Mg) – meta-analysis Oct 2022

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The impacts of vitamin D supplementation in adults with metabolic syndrome: A systematic review and meta-analysis of randomized controlled trials

Front Pharmacol. 2022 Oct 5;13:1033026. doi: 10.3389/fphar.2022.1033026
Kai-Jie Qi 1 , Zhong-Tao Zhao 1 , Wen Zhang 1 , Fang Yang 1

Background: Studies have shown the association of vitamin D status with the development of metabolic syndrome (MetS), which has attracted an extensive research interest with inconsistent results. Therefore, we hypothesized that vitamin D supplementation (VDS) will benefit adults with MetS.

Aims: To test our hypothesis, we performed a meta-analysis to evaluate the effect of VDS on MetS in adults using relevant biomarkers such as anthropometric parameters, blood pressure, blood lipid profile, glycemia, oxidative stress and vitamin D toxicity (VDT).

Methods: Randomized controlled trials published in PubMed, Web of Science, embase and the Cochrane Library between 2012 and 2022 on the effect of VDS on MetS in adults were searched. The language was limited to English. A meta-analysis performed using RevMan 5.4 and Stata 14.0 software, sensitivity analysis, and evaluation of the risk of bias and general quality of the resulting evidence were conducted.

Results: Eventually, 13 articles were included in this meta-analysis. Overall, VDS significantly increased the endline serum 25-hydroxyvitamin D levels as compared to the control [MD:17.41, 95% CI (14.09, 20.73), p < 0.00001].
VDS did not affect

• waist circumference,
• body mass index,
• body fat percentage and
• VDT biomarkers,

but decreased

• waist-to-hip ratio and
• blood pressure (p < 0.01).

VDS significantly decreased

• fasting plasma glucose (FPG) [MD: 3.78; 95% CI (-6.52, -1.03), p = 0.007],

but did not affect the levels of blood

• high-density lipoprotein cholesterol (HDL-C),
• low-density lipoprotein cholesterol (LDL-C),
• total cholesterol (TC), and
• triglyceride (TG).

Pooled estimate of nine papers indicated a significant reduction of

• fasting insulin (FI) (p = 0.006), and
• homeostasis model assessment of insulin resistance (p = 0.0001).

The quantitative insulin check index levels were moderately increased (p = 0.007) without any impact on the glycosylated hemoglobin type A1C (HbA1c). For the oxidative stress parameters, VDS significantly lowered the levels of malondialdehyde and hypersensitive C-reactive protein (p < 0.05).

Conclusion: Results of this meta-analysis demonstrate that VDS only reduces insulin resistance and hypertension but not the blood lipid profile and HbA1c. It appears that the evidence for the benefit of VDS in adults with MetS is inconclusive. Further clinical studies are still needed.
 Download the PDF from Vitamin D Life

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Vitamin D Life - 5 Meta-analyses of Metabolic Syndrome (mainly prevention)

This list is automatically updated

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VitaminDwiki – Metabolic Syndrome contains

All items in category Metabolic Syndrome and Vitamin D 95 items

See also

• Overview Metabolic Syndrome and vitamin D
• Overview Diabetes and vitamin D
• Overview Obesity and Vitamin D
• Metabolic Syndrome risk decreases by 20 percent with each 10 ng increase in Vitamin D - April 2021
• Metabolic Syndrome and Vitamin D - review of 33 studies - March 2021
• Metabolic Syndrome far less likely if high Vitamin D – 3 meta-analyses 2021
• Metabolic Syndrome 11X more likely if have a poor Vitamin D Receptor – 2018
• Vitamin D is linked to metabolic syndrome and obesity – Aug 2019
• Risk of Metabolic syndrome for senior women reduced 42 percent by 1,000 IU of vitamin D – RCT June 2019
• Metabolic Syndrome risk reduced 3.7 X by nuts (Magnesium, Omega-3) – Dec 2018
• Metabolically Healthy – only 1 in 50 seniors in the US – Nov 2018
• Metabolic Syndrome indicators inversely proportional to vitamin D below 46 ng – Nov 2018

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It appears the vitamin D alone can prevent Mestbolic Syndrome but not treat it,

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Metabolic Syndrome Associations with other categories (Note Magnesium)

 Obesity 19;  Diabetes 15;  Cardiovascular 12;  Magnesium 8;  Seniors 8;  Women 5;  Top news 5;  Hypertension 5;  Intervention 5;  Omega-3 4;  Youth 4;  Meta-analysis 4