Overview Vitamin D Dose-Response

Need 9600 IU Vitamin D to get most people to 40 ng – with graph Feb 2011

Vitamin D Supplement Doses and Serum 25-Hydroxyvitamin D in the Range Associated with Cancer Prevention
CEDRIC F. GARLAND 1, CHRISTINE B. FRENCH 2, LEO L. BAGGERLY 2 and ROBERT P. HEANEY 3
1 University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, U.S.A.;
2 GrassrootsHealth, P.O. Box 234208, Encinitas, CA 92023, U.S.A.;
3 Creighton University, 2500 California Plaza, Omaha, NE 68178, U.S.A.

Background: Studies indicate that intake of vitamin D in the range from 1,100 to 4,000 IU/d and a serum 25- hydroxyvitamin D concentration [25(OH)D] from 60-80 ng/ml may be needed to reduce cancer risk. Few community-based studies allow estimation of the dose-response relationship between oral intake of vitamin D and corresponding serum 25(OH)D in the range above 1,000 IU/d.

Materials and Methods: A descriptive study of serum 25(OH)D concentration and self-reported vitamin D intake in a community-based cohort (n=3,667, mean age 51.3 ±13.4 y).

Results: Serum 25(OH)D rose as a function of self-reported vitamin D supplement ingestion in a curvilinear fashion, with no intakes of 10,000 IU/d or lower producing 25(OH)D values above the lower-bound of the zone of potential toxicity (200 ng/ml). Unsupplemented all-source input was estimated at 3,300 IU/d.

The supplemental dose ensuring that 97.5% of this population achieved a serum 25(OH)D of at least 40 ng/ml was 9,600 IU/d.
Need 14,100 IU/d to get 97.5% of the population above 50 ng/ml

Conclusion: Universal intake of up to 40,000 IU vitamin D per day is unlikely to result in vitamin D toxicity

Dose-response graph from the paper

Note: no apparent data below 33 ng and calculation does NOT account for skin color, BMI, latitude, age, co-factors, state of health, etc.

CLICK HERE for PDF

Other interesting graphs in the paper include

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Huge variation in response to each dose (Chart of data by GrassrootsHealth)

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Half of seniors did not respond to 1600 IU of vitamin D daily for a year

RED square = reduction in serum level

from slide presentation: https://www.vitad.org/tiki-index.php?page_id=2269

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Graph of weekly response to monthly vitamin D supplementation – Aug 2015

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See also Vitamin D Life

• On-line Vitamin D response simulation – July 2021
• Response to Vitamin D varied by 12 ng due to gene variants (CYP2R1) – Aug 2019
• Respond to daily Vitamin D in 2-12 months
• Huge variation in response to vitamin D supplementation – personal vitamin D response index – Dec 2016
• 10 reasons for poor response to Vitamin D (race, binding protein, etc.) – Nov 2017
• 24 ng lower response to Vitamin D due to obesity, low initial Vitamin D, and genetics – RCT Feb 2015
• Some people need more vitamin D to get the same response – perhaps due to genes – Nov 2014
• Vitamin D responses to as much as 15,000 IU per day – Feb 2017
• 4700 IU of vitamin D needed by most seniors – an equation -July 2014
• Is 50 ng of vitamin D too high, just right, or not enough
• 85% achieved 20 nanograms with daily average of 3300 IU of vitamin D
• All items in category How Much Vitamin D 342 items
• More response to 1100 IU vitamin D in cold season or less BMI – May 2012
• 800 IU vitamin D resulted in 20 ng, 3200 IU resulted in 45 ng – RCT March 2012
• How to 2X the response to vitamin D supplements
• How to increase the vitamin D you get from time in the sun
• Dose response equation square root of IU
• Recommendations for vitamin D since 2009 both IU and ng/ml
• Overview Loading of vitamin D
  • people who are very vitamin D deficient should consider loading dose to get vitamin D levels as soon as possible
• Vitamin D levels vs weight – RCT Dec 2012
• Higher BMI decreased response to 700 IU vitamin D – RCT 2008
• Grassroots Health participants Vitamin D vs age, intake, and resulting level – Sept 2013
• Overview How Much vitamin D
• Endocrine Society Guideline should be raised to 2 ng per 100 IU of vitamin D – March 2013
• All items in category Predict Vitamin D 79 items
• 50,000 IU vitamin D weekly increased levels by 52 ng normally, but only 28 ng if obese – Oct 2013
• Dose/response graph from GrassRoots
  • Notice that response to 5000 IU varied from 30 ng to 140 ng

• Another dose response graph
  Approx 5,000 IU got the average to 45 ng, while one only got to 24 ng, but another achieved 65 ng

• Response to Vitamin D: summary chart of 8 studies – March 2013 shows 5,000 IU dose would get avg of 60 ng
  • Would higher dose to get a majority (say 97%) above 40 ng

• 200 IU needed to increase vitamin D levels by 1 ng (not 100 IU) – summary of 25 studies – Feb 2014 which has the following chart

• Same dose of vitamin D for everyone is virtually impossible - Dec 2015 has the following, from 36 studies

Short url = http://is.gd/doseresponse