Monthly 120,000 IU of Vitamin D while breastfeeding was good – RCT Jan 2022

Even better: 50,000 IU of vitamin D every 12 days starting a month before pregnancy

Effect of Maternal Supplementation with Two Different Doses of Vitamin D During Lactation on Vitamin D Status, Anthropometry and Bone Mass of Infants: A Randomized Controlled Trial

Indian Pediatr. 2022 Jan 9;S09747559160039
Rekha Ramot 1, Swati Yadav 2, S K Vishnoi 2, Pramod Sharma 2, Rajesh Khadgawat 1, Rakesh Jora 3

Background: There is a high prevalence of vitamin D deficiency (VDD) in exclusively breast-fed infants in the absence of appropriate vitamin D supplementation.

Objective: To evaluate the efficacy of two doses of maternal vitamin D supplementation on vitamin D levels of mother-infant pairs and to assess its effect on growth parameters(weight, length and head circumference) and bone mass of infants.

Study design: Randomized controlled trial.

Participants: Lactating mother-infant pairs (n=220).

Intervention: Maternal oral vitamin D supplementation in two doses (group 1: 120 000 IU/month and group 2: 12000 IU/month for 12 months.

Main-outcomes: Maternal and infant serum 25OHD levels, and infant's growth and bone mass.

Results: There was high prevalence of VDD at baseline in mothers (94%) as well as infants (98.5%) which was reduced to 43.1% in (mothers) and 46.5% in infants after 12 months. Significantly higher median (IQR) serum 25OHD levels (ng/mL) were observed among mothers in group 1 compared to group 2 [46 (17-159) vs 18 (6-64); P<0.01] and in infants [36.5 (15-160) vs 17 (7-32); P<0.01]. No significant association was observed between growth parameters or bone mass and serum 25OHD levels of mother or infant between the two groups. Four mothers (3.6%) and two infants (1.8%) in group I had serum 25OHD>100 ng/mL, but without hypercalciuria or hypercalcemia.

Conclusion: Bolus vitamin D supplementation in the dose of 1,20,000IU/month was more efficacious in improving maternal and infant vitamin D status at 12 months, as compared to 12,000 IU/month.
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RCT = Randomized Controlled Trial

Vitamin D Life - Weekly, Monthly Vitamin D are typically better than daily - many studies