The Efficacy of Vitamin D Supplementation for Migraine: A Meta-Analysis of Randomized Controlled Studies
Clin Neuropharmacol. 2021 Jan-Feb 01;44(1):5-8. doi: 10.1097/WNF.0000000000000419.
Yuan-Feng Zhang 1, Zhi-Qiang Xu, Hong-Jie Zhou, Ya-Zhen Liu, Xiao-Jiang Jiang
Headache has the following on metals and migraines
Compared blood levels of 25 people with migraines to 25 people without GreenMedInfo
| Metal | Migraine | No Migraine | Migraine Ratio |
| Cadmium | 0.36 ug | 0.09 ug | 4X MORE if increase |
| Iron | 0.97 ug | 0.48 ug | 2X MORE if increase |
| Lead | 1.48 ug | 0.78 ug | 2X MORE if increase |
| Magnesium | 10.6 ug | 34.5 ug | 3.5X LESS if increase |
| Zinc * | 0.24 ug | 5.77 ug | 24X LESS if increase |
Introduction: The efficacy of vitamin D for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of vitamin D versus placebo on treatment in migraine patients.
Methods: We search PubMed, EMbase, Web of Science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of vitamin D versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model.
Results: Five randomized controlled trials are included in the meta-analysis. Overall, compared with control group in migraine patients, vitamin D treatment is associated with
- substantially reduced number of headache days
- (standard mean difference [SMD], -0.53; 95% confidence interval [CI], -0.83 to -0.23; P = 0.0006),
- frequency of headache attacks (SMD, -1.09; 95% CI, -1.86 to -0.32; P = 0.006),
- headache severity (SMD, -0.55; 95% CI, -0.91 to -0.19; P = 0.0003), and
- Migraine Disability Assessment score (SMD, -0.76; 95% CI, -1.11 to -0.40; P < 0.0001).
Conclusions: Vitamin D treatment is effective to alleviate migraine.
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