Eppur Si Muove:
vitamin D is essential in preventing and modulating SLE
Lupus May 2016 vol. 25 no. 6 563-572
S Azrielant1, Y Shoenfeld1,2⇑
1The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel
2Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel
Yehuda Shoenfeld, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 5265601, Israel. Email: shoenfel at post.tau.ac.il
Systemic lupus erythematosus (abbreviated SLE or lupus) is a systemic autoimmune disease, with genetic, immunologic, hormonal, and environmental factors.1 One of the environmental factors that has been studied over the years is vitamin D, which is created in the human body in response to exposure to sunlight and ultraviolet (UV) radiation.
This review aims at examining findings from recent years, specifically 2013–2014, regarding the relationship between vitamin D deficiency and SLE flares, severity, and clinical manifestation, as well as to examine the treatment options derived from this relationship.
Publisher wants $40 for PDF, unless patient
See also Vitamin D Life
The TOP articles in Lupus and Vitamin D are listed here:
- Lupus is both prevented and treated by Vitamin D – review Dec 2017
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- If Lupus in family – 5 times more likely to get Lupus if low vitamin D and poor CYP24A1 – June 2016
- Lupus – vitamin D is essential in preventing and modulating it – May 2016
- Juvenile Lupus fatigue reduced by vitamin D ( 50,000 IU weekly for 6 months) – RCT May 2015
- Lupus flareups cut in half by just 2,000 IU of vitamin D – RCT Dec 2012
The TOP articles in Autoimmune and Vitamin D: (LUPUS is an autoimmune disease)
- Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020
- Resveratrol treats Multiple Sclerosis and other autoimmune diseases – many studies
- Multiple Sclerosis – 3X higher incidence in women, previously 1X, wonder why
- Vitamin D is the real Multiple Sclerosis Therapy, not an alternative therapy – Coimbra July 2018
- Stress increased the risk of getting multiple autoimmune diseases by 2.3 X – June 2018
- Vitamin D has treated Multiple Sclerosis and autoimmune diseases for 16 years – Coimbra April 2018
- Autoimmune diseases associated with low Vitamin D and Vitamin D Receptor – July 2017
- Multiple Sclerosis and Vitamin D ~ 50,000 Facebook members in 13 languages – Jan 2017
- Interview of Dr. Coimbra - Vitamin D protocol for Autoimmune diseases – 2016
- Autoimmune disease clusters run in families (polyautoimmunity) are associated with low vitamin D
- Many autoimmune diseases associated with latitude and vitamin D receptor – March 2016
- 1000 IU per kg Vitamin D for autoimmune diseases – Coimbra Aug 2013
- Video by Dr. Coimbra – 95 percent of auto-immune cured with vitamin D in high doses - April 2014
- Chronic Hives treated by Vitamin D - many studies
- Myasthenia gravis score improved 38 percent with just 800 IU of vitamin D daily – Dec 2012
- Vitamin D protects against many types of health problems – review May 2013
- Autoimmune disorder patients in Brazil helped by vitamin D – video and Facebook – Nov 2012
Vitamin D is one of the SLE treatments - June 2016
Immunomodulators in SLE: Clinical evidence and immunologic actions.
J Autoimmun. 2016 Jun 28. pii: S0896-8411(16)30088-9. doi: 10.1016/j.jaut.2016.06.010. [Epub ahead of print]
Durcan L1, Petri M2.
1Division of Rheumatology, University of Washington, Seattle, USA. Electronic address: laurajanedurcan at hotmail.com.
2Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, USA.
Systemic lupus erythematosus (SLE) is a potentially fatal autoimmune disease. Current treatment strategies rely heavily on corticosteroids, which are in turn responsible for a significant burden of morbidity, and immunosuppressives which are limited by suboptimal efficacy, increased infections and malignancies. There are significant deficiencies in our immunosuppressive armamentarium, making immunomodulatory therapies crucial, offering the opportunity to prevent disease flare and the subsequent accrual of damage. Currently available immunomodulators include prasterone (synthetic dehydroeipandrosterone), vitamin D, hydroxychloroquine and belimumab. These therapies, acting via numerous cellular and cytokine pathways, have been shown to modify the aberrant immune responses associated with SLE without overt immunosuppression.
- Vitamin D is important in SLE and supplementation appears to have a positive impact on disease activity particularly proteinuria
- Belimumab has specific immunomodulatory properties and is an effective therapy in those with specific serological and clinical characteristics predictive of response.
- Hydroxychloroquine is a crucial background medication in SLE with actions in many molecular pathways.
It has disease specific effects in reducing flare, treating cutaneous disease and inflammatory arthralgias in addition to other effects such as reduced thrombosis, increased longevity, improved lipids, better glycemic control and blood pressure. - Dehydroeipandrosterone is also an immunomodulator in SLE which can have positive effects on disease activity and has bone protective properties.
This review outlines the immunologic actions of these drugs and the clinical evidence supporting their use.