Higher latitude and lower solar radiation influence on anaphylaxis in Chilean children
Pediatric Allergy and Immunology, Volume 25, Issue 4, pages 338–343, June 2014, DOI: 10.1111/pai.12211
Rodrigo Hoyos-Bachiloglu1,2, Pamela S. Morales1, Jaime Cerda3, Eduardo Talesnik1, Gilberto González4, Carlos A. Camargo Jr5,6 andArturo Borzutzky1,2,*
Background
Recent studies suggest an association between higher latitude, a proxy of vitamin D (VD) status, and allergic diseases. Chile provides an ideal setting to study this association due to its latitude span and high rates of VD deficiency in southern regions. The aim of this study is to explore the associations of latitude and solar radiation with anaphylaxis admission rates.
Methods: We reviewed anaphylaxis admissions in Chile's hospital discharge database between 2001 and 2010 and investigated associations with latitude and solar radiation.
Results
2316 anaphylaxis admissions were registered. Median age of patients was 41 yr; 53% were female. National anaphylaxis admission rate was 1.41 per 100,000 persons per year. We observed a strong north–south increasing gradient of anaphylaxis admissions (β 0.04, p = 0.01), with increasing rates south of latitude 34°S.
A significant association was also observed between solar radiation and anaphylaxis admissions (β −0.11, p = 0.009).
Latitude was associated with food-induced (β 0.05, p = 0.02), but not drug-induced (β −0.002, p = 0.27), anaphylaxis.
The association between latitude and food-induced anaphylaxis was significant in children (β 0.01, p = 0.006), but not adults (β 0.003, p = 0.16). Anaphylaxis admissions were not associated with regional sociodemographic factors like poverty, rurality, educational level, ethnicity, or physician density.
Conclusions
Anaphylaxis admission rates in Chile are highest at higher latitudes and lower solar radiation, used as proxies of VD status. The associations appear driven by food-induced anaphylaxis. Our data support a possible role of VD deficiency as an etiological factor in the high anaphylaxis admission rates found in southern Chile.
PDF is available free at Sci-Hub 10.1111/pai.12211
See also Vitamin D Life
- Allergy - Overview
- 11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013
- 30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012
- 3X more allergy to peanuts if child born with low UV – Feb 2011
- Search Vitamin D Life for anaphylaxis 90 items as of April 2018
- Allergies and asthma – overwhelming experimental evidence that vitamin D helps – more studies needed – Dec 2014
The items in Autoimmune and Infant-Child D are listed here:
- Breastfeeding a child without adding vitamin D increases risk of many food allergies (egg whites in this case) – Jan 2020
- Antibiotics increased the risk of asthma by 47%, and allergies by 25% - Dec 2019
- Low vitamin D newborns getting cows milk formula more likely to get allergies – RCT Oct 2019
- Childhood allergies (Atopy) 4.8 X more likely if low vitamin D in early pregnancy – Aug 2019
- Kawasaki disease (strawberry tongue) not treated by occasional 400 IU of Vitamin D – Feb 2019
- Food allergy is linked to season of birth, sun exposure, and vitamin D deficiency – Jan 2019
- Childhood Food Allergies (UK 1 in 14) – huge recent increase (low vitamin D) - Dec 2018
- Food allergies are associated with Vitamin D thru genes, etc. – March 2018
- Food allergies in children may be due to earlier low Vitamin D, Omega-3 and Zinc – Aug 2017
- T1 Diabetes associated with many other autoimmune diseases (all related to low vitamin D) – May 2017
- Infant allergy to cow’s milk will go away if have high levels of vitamin D – Jan 2017
- Food allergies and low vitamin D – thymus may be the connection – June 2016
- Food allergies 6 times higher in South Australia - 2009
- Hypothesis – Australia has highest rate of food allergy due to avoiding the sun – Sept 2015
- Food allergy 12X more likely if low vitamin D and vitamin D binding gene problem – Aug 2015
- Too much vitamin D: 1 pcnt increase in infants with food allergy, too little: 500 pcnt increase in children with food allergy - Aug 2015
- Kawasaki disease (strawberry tongue) associated with very low vitamin D – May 2015
- Less sun (less vitamin D) more anaphylaxis (severe allergic reaction) – June 2014
- Low vitamin D at birth associated with later milk sensitization, allergic rhinitis and asthma – Nov 2014
- Pink eye (seasonal allergic conjunctivitis) associated with low vitamin D and high vitamin E – March 2014
- 11X more non-immigrant children allergic to peanuts if vitamin D less than 20 ng – Feb 2013
- 30 to 40 ng of vitamin D associated with the least peanut allergy – Nov 2012
- High level of maternal vitamin D and infant food allergy – controversy
- Youths with autoimmunity disorders were 2.3 X more likely to be vitamin D deficient – July 2012
- Still unsure of association between vitamin D and asthma and allergies – review April 2012
- Allergy - Overview
- 3X more allergy to peanuts if child born with low UV – Feb 2011
- More childhood allergies when vitamin D is less than 15 ng – Feb 2011