Vitamin D deficiency in patients with intestinal malabsorption syndromes – think in and outside the gut (invited review)
Journal of Digestive Diseases, Volume 16, Issue 11, pages 617–633, November 2015
Article first published online: 29 DEC 2015, DOI: 10.1111/1751-2980.12283
Samantha L Margulies1, Divya Kurian1, Mark S Elliott2 andZhiyong Han2,*
© 2015 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd
There is a very high prevalence of vitamin D deficiency, which is defined by a serum level of 25-hydroxyvitamin D 25(OH)D of lower than 20 ng/mL, in all populations of the world. Unfortunately, the prevalence of vitamin D deficiency in patients with intestinal malabsorption syndromes, including
- cystic fibrosis (CF),
- celiac disease (CD),
- short bowel syndrome and
- inflammatory bowel disease (IBD),
is higher than that in the general population, indicating the presence of disease-specific causative factors. In this review, we aimed to present clinical findings to highlight the roles of insufficient exposure to sunlight and inflammation in the development of vitamin D deficiency in patients with intestinal malabsorption syndromes. Furthermore, we aimed to present experimental evidence that supported a role of vitamin D deficiency in the pathogenesis of IBD.
Finally, we reviewed clinical intervention strategies aiming to normalize vitamin D status in and even to improve the conditions of patients and to discuss certain issues that needed to be addressed in future research.
One table from the study
Study was rented for $6 by Vitamin D Life
- They notice that those with gut problems have poor time getting vitamin D in thru he gut
- They mention that UV and sublingual might be good ways to get vitamin D
- Little mention of genes
- They seem to not mention many other forms such as topical, spray, injection, and gut-friendly
See also Vitamin D Life
- Overview Gut and vitamin D
- Crohn's disease associated with 7.6X deactivation of Vitamin D receptor – July 2015
- IBD (Collitis, Crohn’s) was active 6X more often if low vitamin D – June 2015
The Meta-analysis of Gut and Vitamin D
- Inflammatory Bowel Disease 1.5 X more likely if low vitamin D – meta-analysis Dec 2019
- Crohn’s Disease associated with lower Vitamin D - meta-analysis Sept 2019
- Inflammatory bowel diseases are associated with Vitamin D etc. – meta-meta-analysis - April 2019
- IBD relapse rate reduced by low Vitamin D - meta-analysis Nov 2018
- Crohn’s disease associated with vitamin D and latitude – meta-analysis Dec 2015
- Gut problems more likely if low vitamin D (IBD: 1.6, UC: 2.3) – meta-analysis Aug 2015
All items in categories Intervention AND Gut
- Diverticular disease:12X reduction if low Vitamin D and given 100,000 IU monthly – RCT Aug 2020
- Irritable Bowel Syndrome treated by weekly 50,000 IU Vitamin D – RCT Feb 2019
- Ulcerative Colitis inflammation treated by weekly vitamin D (40,000 IU) – July 2018
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Vitamin D changed microbiota in gut and airway, might reduce cystic fibrosis – RCT Nov 2017
- Crohn's Disease relapse rate of 3 in 8 with 1,000 IU vs 0 in 12 with 10,000 IU of Vitamin D – RCT Feb 2017
- Ulcerative colitis treated by injection of 300,000 IU of vitamin D – RCT July 2016
- IBS quality of life improved by vitamin D (50,000 IU every two weeks) – RCT May 2016
- IBS – 82 percent had low vitamin D, 3,000 IU spray helped a lot – RCT Dec 2015
- Crohn's disease treated by 2000 IU Vitamin D - RCT June 2015
- Crohn’s disease helped when vitamin D level raised above 30 ng – RCT Feb 2015
- Irritable Bowel Syndrome - can it be treated by 3000 IU of vitamin D - RCT Feb 2014
- Crohn's Disease patients normalizing their Vitamin D levels decreased risk of surgery by 44 percent – Aug 2013
- Crohn’s helped by 5000 IU vitamin D – April 2013
Many ways to increase Vitamin D
click on chart for details