Effect of vitamin D therapy on bone mineral density in patients with diabetic nephropathy; a randomized, double-blind placebo controlled clinical trial
Journal of Diabetes & Metabolic Disorders (2021) https://doi.org/10.1007/s40200-021-00737-y
Gayani Liyanage, Sarath Lekamwasam, Thilak Weerarathna & Chandrani Liyanage
Each of the following have been found to increase bone mineral density
- Enough of a good form of vitamin D for 6+ months (this study)
- Additonal vitamins and minerals which help grow bones (Magnesium, Calcium,silicon, etc)
- Stress on bones(exercise) to tell the body to increase the bone strength
Note: Bone strength is a much better indicator of Bone Mineral Density, but is rarely available
Poor guts need different forms of vitamin D
Guesses of Vitamin D response if poor gut
Bio | Form | Speed | Duration |
10 | Injection ($$$) or Calcidiol or Calcitriol | D - Slow C -Fast | Long |
10 | Sun/UVB | Slow | Long |
10 | Topical (skin patch/cream, vagina) | Slow Fast nano | Normal |
9 | Nanoemulsion -mucosal perhaps activates VDR | Fast | Normal |
9? | Inhaled (future) | Fast | Normal |
8 | Bio-D-Mulsion Forte | Normal | Normal |
6 | Water soluble (Bio-Tech) | Normal | Normal |
4 | Sublingual/spray (some goes into gut) | Fast | Normal |
3 | Coconut oil based | Slow | Normal |
2 | Food (salmon etc.) | Slow | Normal |
2 | Olive oil based (majority) | Slow | Normal |
10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months
Falls and Fractures category contains the following
222 items in FALLS and FRACTURES - see also Overview Seniors and Vitamin D
- Overview Fractures and Falls and Vitamin D
- Deaths due to falls doubled in just a decade (age-adjusted, perhaps decreased vitamin D) – June 2019
- Preventing Falls in Older Adults – Vitamin D combination is the best - JAMA Meta-analysis Nov 2017
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- Vitamin D prevents falls – majority of meta-analyses conclude – meta-meta analysis Feb 2015
- Vitamin D and fractures – 24 meta-analyses and counting – Dec 2014
Hip fracture
- Search Vitamin D Life for "HIP FRACTURE" 191 items not in PDF as of July 2020
- A call to action: Vitamin D for hip fracture (50,000 weekly for 8 weeks, then bi-weekly – Holick July 2020
- Risk factors for death after hip fracture surgery – 7 of the 8 are associated with low vitamin D – Aug 2020
- 3.5 X higher risk of death 2 years after hip fracture surgery if low vitamin D – Jan 2020
- Hip fracture recovery best with home exercise plus Vitamin D – RCT Dec 2018
- Hip fracture 58 percent more likely if low vitamin D – meta-analysis March 2017
- Fracture risk 40 percent higher risk if low Vitamin D - June 2019
- 1 in 3 died after hip fracture but only 1 in 14 if add Vitamin D and exercise – RCT April 2017
Injection category listing has
56 items - Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Calcium from plants might be OK – Dec 2016
- Vitamin D monotherapy for just 3 months did not improve bone turnover – Oct 2012
- Silicon or silica as a vitamin D co-factor
- Hypothesis: increased bone mineral density needs protein, Ca, Mg, Vitamin D and K
- Osteoporosis treatment with denosumab is helped by Vitamin D and Calcium – 2017
Bone - Health category starts with the following
272 items in Bone - Health category
See also- Overviews: Osteoporosis, Fractures, Rickets Dental Hair
-
14 articles are in both Bone and Magnesium categories 25 articles are in both Bone and Vitamin K2 categories 11 articles are in both Bone and Sports categories 7 articles are in both Bone and Meta-analysis categories 23 articles are in both Fractures and Meta-analysis categories - Healthy bones need: Calcium, Vitamin D, Magnesium, Silicon, Vitamin K, and Boron – 2012
- Search Vitamin D Life for BMD OR "Bone Mineral Density" 2240 results as of Nov 2019
- Hearing loss is associated with soft bones in ear
- Perhaps prevented and treated by Vitamin D
Purpose
Diabetes compromises bone strength resulting increased risk of osteoporosis. Objective of this study was to determine the effect of vitamin D given to patients with early diabetic renal disease on BMD and BMC.Methods
Patients with diabetic nephropathy were recruited. Treatment group received 50,000 IU of vitamin D3 intramuscularly and the control group was given an equal volume of distilled water (0.25 mL) monthly for six months. Baseline BMD, BMC in the total body, lumbar spine and proximal femur were measured by DXA. After six months measurements were repeated. When trial period was over, a randomly selected subgroup of patients (25 from each group) was followed up for further six-months and measurements were repeated.Results
Selected patients were randomly assigned to two groups. After six months, the treatment group total body BMD, total body BMC and BMDs of spine, femoral neck and total hip regions increased by 2.0%, 2.2%, 1.8%, 2.1% and 2.6% (P < 0.05 for all within-group differences), respectively. In the Control group, BMD or BMC of any region mentioned above did not change significantly during the initial 6 months (P < 0.05 for the between-groups differences). After 6 months of stopping treatment, a statistically significant reduction of total BMD and BMC was observed in the treatment group (P = 0.009).Conclusion
This study showed that treatment with high dose vitamin D significantly influences total body BMC, total body BMD, BMDs of spine, femoral neck and hip among patients with diabetic nephropathy.Bone density improved by monthly 50,000 IU of vitamin D for 6 months – RCT Jan 202165 visitors, last modified 19 Jan, 2021, This page is in the following categories (# of items in each category)