Vitamin D and Ageing
Biochemistry and Cell Biology of Ageing: Part I Biomedical Science pp 191-220
Tom R. Hill. Antoneta Granic, Terence J. Aspray
10 reasons why seniors need more vitamin D has the following
- Senior skin produces 3X less Vitamin D for the same sun intensity
- Seniors have fewer vitamin D receptors as they age
(The effect of low Vitamin D receptor genes does not show up on vitamin D test results) - Seniors are indoors more than when when they were younger
not as agile, weaker muscles; frail, no longer enjoy hot temperatures
(if outside, stay in the shade), however, seniors might start outdoor activities like gardening, biking, etc. - Seniors wear more clothing outdoors than when younger
fear skin cancer/wrinkles, sometimes avoid bright light after cataract surgery - Seniors often take various drugs which reduce vitamin D (some would not show up on vitamin D test) statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
- Seniors often have one or more diseases which consume vitamin D ( osteoporosis, diabetes, MS, ...)
- Seniors generally put on weight at they age - and a heavier body requires more vitamin D
- Seniors often (40%) have fatty livers – which do not process vitamin D as well
- Seniors not have as much Magnesium needed to use vitamin D
(would not show up on vitamin D test) - Seniors with poorly functioning kidneys do not process vitamin D as well
(would not show up on vitamin D test) 2009 full text online Also PDF 2009 - Vitamin D is not as bioavailable in senior digestive systems (Stomach acid or intestines?)
- Category Seniors and Vitamin D
341 items The risk of 40 diseases at least double with poor Vitamin D Receptor as of July 2019
Vitamin D Receptor table shows what compensates for low VDR activation
Compensate for poor VDR by increasing one or more:Increasing Increases 1) Vitamin D supplement
Sun, Ultraviolet -BVitamin D in the blood
and thus in the cells2) Magnesium Vitamin D in the blood
AND in the cells3) Omega-3 Vitamin D in the cells 4) Resveratrol Vitamin D Receptor 5) Intense exercise Vitamin D Receptor 6) Get prescription for VDR activator
paricalcitol, maxacalcitol?Vitamin D Receptor 7) Quercetin (flavonoid) Vitamin D Receptor 8) Zinc is in the VDR Vitamin D Receptor 9) Boron Vitamin D Receptor ?,
etc10) Essential oils e.g. ginger, curcumin Vitamin D Receptor 11) Progesterone Vitamin D Receptor 12) Infrequent high concentration Vitamin D
Increases the concentration gradientVitamin D in the cells 13) Sulfroaphone and perhaps sulfur Vitamin D Receptor Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Items in both categories Seniors and Vitamin D Receptor are listed here:
- Sarcopenia (muscle loss) is 1.6X more likely if poor Vitamin D receptor – July 2020
- Parathyroid increase with age associated with worsening Vitamin D genes – April 2020
- Reduced muscle function in mice lacking Vitamin D Receptors in muscles – June 2019
- Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019
- Less vitamin D gets to cells as you age - fewer Vitamin D Receptors - 2004
- Aging leads to a decrease of vitamin D getting to cells – Sept 2017
- Sepsis is 13 X more likely if poor Vitamin D Receptor – April 2017
- Centenarians have good Vitamin D Receptor genes (or take lots of vitamin D) – March 2016
- 10 reasons why seniors need more vitamin D
Download the PDF from Sci-Hub via Vitamin D Life
One hundred years has passed since the discovery of vitamin D as the active component of cod-liver oil which cured the bone disease rickets. Since then our knowledge of vitamin D has expanded tremendously and has included recognition of the importance of UV radiation as a source of the vitamin as well as the discovery of the vitamin as a nutrient, a pro-hormone and a potent steroid hormone with a major role in calcium and bone metabolism. In the last 25 years or so, the discovery of the vitamin D receptor in over 30 different body tissues together with the existence of the alpha-1-hydroxylase enzyme in these tissues provided evidence of a pleiotropic role of vitamin D outside its classical role in the skeleton. These important discoveries have provided the basis for the increasing interest in vitamin D in the context of nutritional requirements for health including the prevention of chronic diseases of ageing. The recent publication of the Dietary Reference Intake report on vitamin D and calcium by the North American Institute of Medicine (IOM) is the most comprehensive report to date on the basis for setting nutritional requirements for vitamin D. This chapter will summarize the nutritional aspects of vitamin D and discuss the changes in vitamin D metabolism and requirements with ageing. It will summarize key evidence on the relationship between vitamin D status and some of the main ageing related health outcomes including bone, muscle and cognitive health as well as survival focusing on the published literature in very-old adults (those >= 85 years of age).
Clipped from PDF
Dermal Vitamin D Production
The dermal capacity to produce vitamin D in persons aged 65 years has been estimated to be about 25% of that in persons aged 20-30 years exposed to the same amount of sunlight (Holick et al. 1989; MacLaughlin and Holick 1985). This reduction cannot be explained by the decrease in mass of the epidermis with ageing, but rather seems to be related to the reduction in the concentration of skin 7-dehydrocholesterol. Other indirect factors which affect exposure to sunlight in older adults include the wearing of more concealing clothing (Matsuoka et al. 1992), an increased use of sunscreen (Holick 1994), and reduced sun exposure, arising from less physical activity and time outdoors compared with younger age groups (Health Survey for England 2008).
Changes in VDR Numbers
Vitamin D deficiency is associated with muscle weakness which potentially increases the risk of falls and fractures, possibly mediated through effects on 1,25(OH)2D3 receptors which have been discovered in muscle (Simpson et al. 1985; Bischoff et al. 2001). Bischoff-Ferrari et al. demonstrated a strong negative correlation between age and VDR expression in muscle as measured by the number of VDR-positive nuclei per 500 counted nuclei (Bischoff-Ferrari et al. 2004). This association was independent of biopsy location and circulating 25(OH)D concentrations. This finding may have significant clinical ramifications in older age owing to the importance of 1,25(OH)2D3 in regulating transcription of muscle related genes. The role of vitamin D in muscle atrophy in older adults has been reviewed by Dawson- Hughes (2012) and will be discussed later in this chapter.See also Vitamin D Life Aging leads to a decrease of vitamin D getting to cells – Sept 2017
Vitamin D and Ageing (29 page chapter, VDR decreases with age) – Feb 2019Printer Friendly PDF this page! Follow this page for updates1192 visitors, last modified 12 Jul, 2019, This page is in the following categories (# of items in each category)