13 reasons why many seniors need more vitamin D (both dose and level) - July 2023

1. Senior skin produces 4X less Vitamin D for the same sun intensity
2. Seniors have fewer vitamin D receptor genes as they age
   Receptors are needed to get Vitamin D in blood actually into the cells
3. Many other Vitamin D genes decrease with age
4. Since many gene activations are not detected by a blood test,
   more Vitamin D is often needed, especially by seniors
5. Seniors are indoors more than when they were younger
   not as agile, weaker muscles; frail, no longer enjoy hot temperatures
6. Seniors wear more clothing outdoors than when younger
   Seniors also are told to fear skin cancer & wrinkles
7. Seniors often take various drugs which end up reducing vitamin D
   Some reductions are not detected by a vitamin D test of the blood
   statins, chemotherapy, anti-depressants, blood pressure, beta-blockers, etc
8. Seniors often have one or more diseases that consume vitamin D
   osteoporosis, diabetes, Multiple Sclerosis, Cancer, ...
9. Seniors generally put on weight as they age - and a heavier body requires more vitamin D
10. Seniors often (40%) have fatty livers – which do not process vitamin D as well
11. Reduced stomach acid means less Magnesium is available to get vitamin D into the cells
12. Vitamin D is not as bioavailable in senior intestines
13. Seniors with poorly functioning kidneys do not process vitamin D as well
       Seniors category has 428 items

Vitamin D Life - Genetics chart shows the vitamin D genes

Some genes reduce Vitamin D (Calcidiol) in blood from getting to senior cells

• Genes which regulate active vitamin D worsen with age – Oct 2016
• No response to vitamin D 7X more likely if poor CYP24A1 or VDBP genes - Feb 2023
• Vitamin D non-responders may have one or more poor genes: GC, LIPC, CYP24A1, and PDE3B – Oct 2022
• 3X higher risk of oral cancer if CYP27B1 and CYP24A1 genes were different – May 2012
• Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
• Kidney Stones are related to poor genes – example of CYP24A1 (Vitamin D) – Nov 2019
• Acute Coronary Syndrome is associated with poor Vitamin D genes (CYP27B1, CYP24A1) – Nov 2019
• CYP24A1 gene in cancer cells may actually remove vitamin D from the blood – Oct 2012
• Colon cancer 30 percent more likely if problems with Vitamin D genes CYP24A1 or CYP27B1 – Nov 2015
• Prostate Cancer – Vitamin D – CYP27B1 – CYP24 – June 2011

Vitamin D Life - 11 studies in both categories Seniors and Vitamin D Receptor

This list is automatically updated

Skin of seniors generates less Vitamin D

Wonder what % of the "diseases of aging" are due to low vitamin D?

The Blue Zone books show seniors in their 90's who are active in gardens (getting lots of vitamin D - as well as exercise, good food, etc.)

• Why do gardeners live longer (vitamin D, etc.)

See also Vitamin D Life

• Overview Seniors and Vitamin D
• 20 reasons for not taking Vitamin D debunked
• Many diseases of aging are associated with low vitamin D – Dec 2014
• Many reasons why vitamin D deficiency has become epidemic 40 reasons as of Feb 2024
• Hypothesis: Sarcopenia and other senior problems are related to low gastric acid
• Elderly often trapped in vitamin D vicious circles
• 4700 IU of vitamin D needed by most seniors – an equation -July 2014

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