Relationship Between Dietary Vitamin D and Deaths From Stroke and Coronary Heart Disease – The Japan Collaborative Cohort Study
Stroke. 2017; https://doi.org/10.1161/STROKEAHA.117.019417
Haytham A. Sheerah, Ehab S. Eshak, Renzhe Cui, Hironori Imano,, Hiroyasu Iso, Akiko Tamakoshi
Stroke
Overview Stroke and vitamin D
Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
Stroke mortality 3X worse among seniors with less than 26 ng of vitamin D – June 2014
Large vessel Ischemic Stroke 13 X more likely if low vitamin D – Nov 2017
Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
Stroke results in 8 years of cognitive decline (vitamin D not mentioned) May 2015
Cardiovascular
Overview Cardiovascular and vitamin D
Major heart problems avoided if have high vitamin D – 234,000 people Nov 2015
Cardiovascular Diseases and Vitamin D – Review Feb 2015
7X increased chance of death if coronary artery disease and low vitamin D – Oct 2013
Cardiovascular category starts with the following
- Overview Cardiovascular and vitamin D
- Hypertension and vitamin D
- Overview Metabolic Syndrome and vitamin D
- Overview Stroke and vitamin D
- Peripheral arterial disease risk is 1.5X higher if low vitamin D – meta-analysis March 2018
- Peripheral Arterial Disease 3.7 X more likely in diabetics with low vitamin D – June 2019
- Heart attack ICU costs cut in half by Vitamin D – Oct 2018
Meta-analyses
- Heart Failure and Vitamin D meta-analyses - 2016, 2019
- Cardiovascular death 1.5X more likely if less than 20 ng of Vitamin D – 22nd meta-analysis Nov 2019
- Vitamin D supplementation reduces many Cardiovascular Disease markers– meta-analysis July 2018
Omega-3 Helps
- Cardiovascular Prevention with Omega-3 (finally using high doses) – Sept 2019
- Higher Omega-3 index (4 to 8 percent) associated with 30 percent less risk of coronary disease (10 studies) July 2017
A poor Vitamin D Receptor can block Vitamin D in blood from getting to tissues
- Heart Failure 15X more likely if poor VDR, even if good level of vitamin D (China) – March 2019
- Coronary Artery Disease without diabetes 5 times more likely if VDR gene problems – meta-analysis May 2016
Cholesterol, Statins
- Cholesterol is needed to produce both Vitamin D and Cortisol
- Overview Cholesterol and vitamin D
- Statins and vitamin D statins often reduce levels of vitamin D
- Statin side-effects are reduced by Vitamin D – US patent Application – April 2019
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Background and Purpose—There is growing evidence about the importance of vitamin D for cardiovascular health. Therefore, we examined the relationship between dietary vitamin D intake and risk of mortality from stroke and coronary heart disease in Japanese population.
Methods—A prospective study encompassing 58 646 healthy Japanese adults (23 099 men and 35 547 women) aged of 40 to 79 years in whom dietary vitamin D intake was determined via a self-administered food frequency questionnaire. The median follow-up period was 19.3 years (1989–2009). The hazard ratios and 95% confidence intervals of mortality were calculated using categories of vitamin D intake.
Results—During 965 970 person-years of follow-up, 1514 stroke and 702 coronary heart disease deaths were documented. Vitamin D intake was inversely associated with risk of mortality from total stroke especially intraparenchymal hemorrhage but not from coronary heart disease; the multivariable hazard ratios (95% confidence intervals) for the highest (≥440 IU/d) versus lowest (<110 IU/D) categories of vitamin D intake were 0.70 (0.54–0.91; P for trend=0.04) for total stroke and 0.66 (0.46–0.96; P for trend=0.04) for intraparenchymal hemorrhage.
Conclusions—Dietary vitamin D intake seems to be inversely associated with mortality from stroke.