Parkinson's disease cognitive decline associated with poor Vitamin D receptor – Nov 2016

Vitamin D receptor gene polymorphisms and cognitive decline in Parkinson's disease.

J Neurol Sci. 2016 Nov 15;370:100-106. doi: 10.1016/j.jns.2016.09.013. Epub 2016 Sep 11.
Gatto NM1, Paul KC2, Sinsheimer JS3, Bronstein JM4, Bordelon Y4, Rausch R4, Ritz B5.

We and others have suggested that vitamin D receptor gene (VDR) polymorphisms influence susceptibility for Parkinson's disease (PD), Alzheimer's disease (AD), mild cognitive impairment (MCI) or overall cognitive functioning. Here we examine VDR polymorphisms and cognitive decline in patients with PD. Non-Hispanic Caucasian PD patients (n=190) in the Parkinson Environment Gene (PEG) study were successfully genotyped for seven VDR polymorphisms. Cognitive function was assessed with the Mini-Mental State Exam (MMSE) at baseline and at a maximum of three follow-up exams. Using repeated-measures regression we assessed associations between VDR SNP genotypes and change in MMSE longitudinally. PD cases were on average 67.4 years old at diagnosis and were followed for an average of 7.1 years into disease.

Each additional copy of the FokI A allele was associated with a 0.115 decrease in the total MMSE score per year of follow-up (β=-0.115, SE(β)=0.05, p=0.03) after adjusting for age, sex, education and PD duration. The effect on MMSE by the FokI A allele was comparable in absolute magnitude to the effect for disease duration in years prior to first interview (β=-0.129 per year, SE(β)=0.08, p=0.13), and years of education (β=0.118 per year, SE(β)=0.03, p<0.001). When LD/LED use and PD subtype were added to the model, the effect of the FokI A allele on total MMSE score was magnified (β=-0.141, SE(β)=0.05, p=0.005). Results point to Fokl, a functional VDR polymorphism, as being associated with cognitive decline in PD. Future studies examining the contributions of the vitamin D metabolic pathway to cognitive dysfunction in PD are needed.

Copyright © 2016 Elsevier B.V. All rights reserved. Publisher wants $36 for the PDF

PMID: 27772736 DOI: 10.1016/j.jns.2016.09.013

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See also Vitamin D Life

Vitamin D Receptor category has the following

384 studies in Vitamin D Receptor category

Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )

A poor VDR increases the risk of 55 health problems  click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR

Compensate for poor VDR by increasing one or more:

Increasing	Increases
1) Vitamin D supplement   Sun, Ultraviolet -B	Vitamin D in the blood and thus in the cells
2) Magnesium	Vitamin D in the blood  AND in the cells
3) Omega-3	Vitamin D in the cells
4) Resveratrol	Vitamin D Receptor
5) Intense exercise	Vitamin D Receptor
6) Get prescription for VDR activator    paricalcitol, maxacalcitol?	Vitamin D Receptor
7) Quercetin (flavonoid)	Vitamin D Receptor
8) Zinc is in the VDR	Vitamin D Receptor
9) Boron	Vitamin D Receptor ?, etc
10) Essential oils e.g. ginger, curcumin	Vitamin D Receptor
11) Progesterone	Vitamin D Receptor
12) Infrequent high concentration Vitamin D Increases the concentration gradient	Vitamin D in the cells
13) Sulfroaphone and perhaps sulfur	Vitamin D Receptor

Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above

Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR

Overview Parkinsons and Vitamin D contains the following summary
Parkinson's Disease proven to be TREATED by Vitamin D (Many Meta-analyses of trials)

• Parkinson's disease stabilized with just 1200 IU of vitamin D – RCT May 2013
  First RCT to report results - +anticipate far better results when more vitamin D is used.
     (Belief based on the results with vitamin D on MS and Diabetes)
  Additonal proofs that vitamin D treats or prevents diseases
• 6 clinical trials for PD with vitamin D intervention as of Jan 2016
  A person could wait a few years to get the results of the clinical trials, but
• Based on reading more than 4,000 studies of vitamin D at Vitamin D Life
• A (loading) dose of 20,000 IU of vitamin D daily for the 3 weeks should provide observable benefit
  To avoid a rare reaction to Vitamin D
  take 1,000 IU of vitamin D first, and stop if you you have an allergic reaction withiin 3 days
  When continuing to take vitamin D you should also take cofactors
  There is virtually no need have a vitamin D test in first 2 months
•    Parkinson's category has 82 items