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Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014

Microbial production of 1α-hydroxyvitamin D3 from vitamin D3.

Nat Prod Res. 2014 Jan 23.
Ahmed SA, Mesbah MK, Youssef DT, Khalifa SI.
Department of Pharmacognosy , Faculty of Pharmacy, Suez Canal University , Ismailia , Egypt.

The microbial transformation of vitamin D3 (1) by the fungi Candida maltosa R42 and Botrytis allii NRRL 2502 was investigated. Incubation of compound 1 with C. maltosa R42 and B. allii NRRL 2502 produced the same three more polar metabolites in small yields. The main metabolite was identified as 1α-hydroxyvitamin D3 (2). This biotransformation has utility as a possible tool for the production of 1α-hydroxyvitamin D3 from the readily available vitamin D3 for patients with compromised kidney function.

PMID: 24456427 Publisher charges $46 for the PDF

See also Vitamin D Life

Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014

2613 visitors, last modified 24 Dec, 2016,

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- Modified release active Vitamin D (calcifediol ) for those with poor Kidney function (USD 10,000 per year) – April 2015 The eyes can also activate vitamin D – Feb 2014 The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016 Vitamin D activation is mainly done by the tissues, not the Kidneys Vitamin D3 becomes Calcidiol which becomes Calcitriol

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