Vitamin D activation is mainly done by the tissues, not the Kidneys

Speculation of the full activation of Vitamin D by the tissues has ranged from 50% up to 90%
Many charts of Vitamin D activation only show the liver & Kidney, and ignore activation by tissues

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85% activation by Tissues – 2011

New vitamin D analogs and changing therapeutic paradigms.
Kidney Int. 2011 Apr;79(7):702-7. doi: 10.1038/ki.2010.387. Epub 2010 Oct 20.
Cunningham J1, Zehnder D.
Centre for Nephrology, UCL Medical School, Royal Free Campus, London, UK. drjohncunningham at googlemail.com
 Download the PDF from Vitamin D Life

Vitamin D compounds have been used successfully to treat secondary hyperparathyroidism for almost three decades. Side effects of increased levels of serum calcium and phosphate and potential complications have increasingly been recognized as problematic, and this has become an even more difficult clinical challenge with the desire to capitalize on some of the pleiotropic effects of vitamin D. Nonclassical nuclear vitamin D receptor (VDR) effects on the cardiovascular system, kidneys, and immune system, with the prospect of improved patient survival, have moved to center stage. Selective vitamin D compounds with minimal effects on mineral metabolism and with maximal cardiovascular and renal benefits are now needed. New vitamin D compounds already in clinical use, which have an improved side-effect profile and differential nonclassical effects compared with calcitriol, are limited to the three licensed pharmaceuticals: paricalcitol, 22-oxacalcitriol, and doxercalciferol. Other compounds are under early development and it is anticipated that these novel therapeutic concepts will result in new vitamin D therapies that will help to reduce the high mortality rate patients with kidney disease experience.
__61 citations of this study as of Nov 2019

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2 Activation paths have some different genes

Genetics category listing contains the following

266 articles in the Genetics category

see also

• 384 articles in Vitamin D Receptor
• 141 articles in Vitamin D Binding Protein = GC
• 35 articles in CYP27B1
• Topical Vitamin D
• Nanoemulsion Vitamin D may be a substantially better form
• Getting Vitamin D into your body

Vitamin D blood test misses a lot

• Snapshot of the literature by Vitamin D Life as of early 2019
• Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
• Note: Good blood test results (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
• A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
•    Commercially available 2019
  • However test results would vary in each tissue due to multiple genes
• Good clues that Vitamin D is being restricted from getting to the cells
  1) A vitamin D-related health problem runs in the family
  • especially if it is one of 51+ diseases related to Vitamin D Receptor
  
  2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
  3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
  • easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
  
  4) Back Pain
  • probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
    • The founder of Vitamin D Life took action with clues #3&4

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See also Vitamin D Life

• Vaginal Vitamin D reduced vaginal infections - Jan 2014 local application
• Malignant melanoma may be reduced by skin-activated vitamin D – Nov 2016
• The eyes can also activate vitamin D – Feb 2014
• PhD Dissertation - Local production of active vitamin D inhibits Prostate Cancer – Oct 2012
• Kidney not essential for Vitamin D3 activation – fungi can do it – Jan 2014
• Bones can activate vitamin D – July 2013
• Perhaps even mitochondria can activate vitamin D – April 2013
• Itchy skin (pruritus) due to kidney disease was treated with topical vitamin D – April 2015
• Topical Vitamin D