Loading...
 
Toggle Health Problems and D

Hypertension risk increased 2.1 X if poor Vitamin D Receptor – Dec 2019

Low serum 25-hydroxyvitamin D levels may increase the detrimental effect of VDR variants on the risk of essential hypertension.

Eur J Clin Nutr. 2019 Dec 11. doi: 10.1038/s41430-019-0543-5.
Shen F1, Guo C2, Wang Y1, Yu F1, Zhang D1, Liu X3, Ba Y4, Wang C3, Li W5, Li X6.

Vitamin D Life

Hypertension category listing contains the following

134 items in the category HYPERTENSION

see also
Overview Hypertension and vitamin D
Overview Cardiovascular and vitamin D
Overview Stroke and vitamin D
Incidence of 22 health problems related to vitamin D have doubled in a decade
160% increase per decade (women, age adjusted)
Image


Items in both categories Hypertension and Vitamin D Receptor are listed here:


The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019

Vitamin D Receptor Activation can be increased by any of: Resveratrol,  Omega-3,  Magnesium, Zinc Quercetin,  non-daily Vit D.  Curcumin, intense exercise,  Ginger,  Essential oils, etc  Note: The founder of Vitamin D Life uses 10 of the 12 known VDR activators

Resveratrol improves health (Vitamin D receptor, etc.) has the following

  • The Vitamin D Receptor can restrict how much of the Vitamin D in the blood actually gets to cells
  • Resveratrol is one of 11 ways to negate the Vitamin D Receptor restrictions
  • Resveratrol is produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fung
  • Benefits of Reseveratrol, like Vitamin D, appears to be increased when used with other things
    • Quercetin and Curcumin in the case of Resveratro

The articles in both of the categories Resveratrol and Vitamin D Receptor

BACKGROUND/OBJECTIVES:
The present cross-sectional study evaluated the association of vitamin D receptor (VDR) variants with serum 25(OH)D3 levels and their interaction on essential hypertension (EH) risk.

SUBJECTS/METHODS:
1539 patients were eligible in the study population. Two loci in VDR gene (rs2239179, rs2189480) were genotyped by TaqMan probe assays. Logistic regression, Kruskal-Wallis rank test and Chi-square test were used to determine the association among VDR polymorphisms, serum vitamin D metabolites, and the risk of EH. Interaction plots were performed to explain the interaction effects of circulating 25(OH)D3 levels and VDR variants on EH susceptibility.

RESULTS:
After potential confounding adjustment, we observed that the mutations of VDR (rs2239179/rs2189480) were associated with the increased risk of EH (P < 0.05). Moreover, plasma 25(OH)D3 levels were inversely associated with EH, However, we did not find the association between serum 25(OH)D3 and VDR variants. When comparing with wild-type homozygous and heterozygous genotype carriers with vitamin D sufficiency, hypovitaminosis D and insufficient participants carrying homozygous variant genotype of rs2239179 showed a higher risk of EH, increased by 113% (OR = 2.13, 95% CI: 1.20, 3.80); Notably, the detrimental effect of rs2239179 homozygous variant on EH became stronger in the case of serum 25(OH)D3 <30 ng/ml. However, we did not find the interaction effect between rs2189480 variants and serum 25(OH)D3 levels on the risk of EH.

CONCLUSIONS:
Our results suggested that the mutations of VDR may accelerate the progression of EH etiology, especially when suffering hypovitaminnosis D and insufficiency.


Created by admin. Last Modification: Friday December 13, 2019 13:16:40 GMT-0000 by admin. (Version 3)
See any problem with this page? Report it (FINALLY WORKS)