Hypertension, Vitamin D, and Vitamin D Receptor – Aug 2019

Vitamin D and Vitamin D Receptor: New Insights in the Treatment of Hypertension.

Curr Protein Pept Sci. 2019 Aug 7. doi: 10.2174/1389203720666190807130504
Lin L1, Zhang L1, Li C1, Gai Z1, Li Y1.
Shandong University of Traditional Chinese Medicine, 250003 Ji-nan. China.

Vitamin D, as a natural medicine, is known to regulate calcium and phosphate homeostasis. But abundant research has shown that vitamin D also plays a regulatory role in autoimmunity, inflammation, angiogenesis and vascular cell activity. Since the vitamin D receptor (VDR) is widely distributed in vascular endothelial cells, vascular smooth muscle cells and cardiomyocytes, the role of vitamin D and VDR in hypertension has received extensive attention. Hypertension is a disease with high incidence and high cardiovascular risk. In recent years, both clinical trials and animal experiments have shown that vitamin D plays a regulatory role in decreasing blood pressure (BP) through inhibiting renin- angiotensin-aldosterone system activity, modulating function of vascular wall and reducing vascular oxidative stress.
A growing body of data suggest that vitamin D deficiency is associated with increased cardiovascular disease risk in hypertension, even short-term vitamin D deficiency may directly raise BP and promote target organ damage.
Due to the high correlation between vitamin D and hypertension, vitamin D supplementation therapy may be a new insight in the treatment of hypertension. The aim of this review will explore the mechanisms of the vitamin D and VDR in regulating the BP and protecting against the target organ damage.