Association of vitamin D and vitamin B12 with cognitive impairment in elderly aged 80 years or older: a cross‐sectional study
M. I. da Rosa W. O. Beck T. Colonetti J. Budni A. C. B. Falchetti L. Colonetti A. S. Coral F. O. Meller
Journal of Human Nutrition and Diatetics https://doi.org/10.1111/jhn.12636
Consensus: Low Vitamin D is associated with poor cognition
Cognitive category starts with the following
Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search Vitamin D Life for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search Vitamin D Life for "WHITE MATTER" 53 items as of Jan 2017
37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn
Types of evidence that Vitamin D helps brain problems - 2014
Seem to lack a consensus about Vitamin B12 and cognition
Items in both categories Cognitive and Vitamin B12 are listed here:
- Cognitive decline 2X more likely if low Vitamin D or high Vitamin B12 – Feb 2019
- Autistics and Schizophrenics have 3X lower Vitamin B12 levels in the brain – Jan 2016
- Vitamin B12
- Do You Believe the Myth That You Can't Prevent Alzheimer's – Mercola, Aug 2017
- Schizophrenia might be treated by folic acid, vitamin B12 and vitamin D – May 2014
Background: The present study aimed to assess the association of vitamin D and vitamin B12 with cognitive impairment in elderly people.
Methods
The data were obtained from a cross‐sectional study that included individuals aged 80 years or older living in the urban and rural areas of the cities of Siderópolis and Treviso in the state of Santa Catarina, Brazil. In total, 165 elderly people were included in the analysis. The outcome of cognitive decline was assessed by the Mini‐Mental State Examination. Vitamin D and vitamin B12 levels were measured from blood samples. The socio‐demographic, anthropometric and health variables used in the analysis were collected from a questionnaire. Crude and adjusted analyses of the relationship between vitamins D and B12 and cognitive decline were performed using a Poisson regression model.
Results
The prevalence of cognitive decline was 35.2%. In the adjusted model, individuals who had vitamin D levels >19 ng mL−1 showed a lower prevalence of cognitive decline (prevalence ratio = 0.59; 95% confidence interval = 0.39–0.87). Those participants who had vitamin B12 levels of ≥496 pg mL−1 had a higher prevalence of cognitive decline (prevalence ratio = 1.90; 95% confidence interval = 1.08–3.36).
Conclusions
The present study showed that individuals aged ≥80 years who had vitamin D levels of ≤18 ng mL−1 had a higher prevalence of cognitive decline even after adjustment for potential confounders. In addition, the study demonstrated that vitamin B12 levels of ≥496 pg mL−1 in this population were also a risk factor for cognitive decline. A cross‐sectional analysis does not enable the inference of a cause–effect relationship and additional studies are needed to understand these relationships.
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