Vitamin D Status and Immune Health Outcomes in a Cross-Sectional Study and a Randomized Trial of Healthy Young Children
Nutrients 2018, 10(6), 680; https://doi.org/10.3390/nu10060680
- Vitamin D levels were about 60 nmol both before and after the 600 IU for 12 weeks
- A small % of children did get about 75 nmol of vitamin D saw improved immune health,
but there were so few that no statistical significance could be assigned.
See also Vitamin D Life
- Viral Pneumonia in children 52 X more-likely if very low vitamin D (trend) – June 2017
- Childhood asthma problems eliminated for months by 600,000 IU of Vitamin D injection – June 2017
- Respiratory tract infections in childhood – vitamin D is needed, no consensus of how much – Oct 2015
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- 400 IU of Vitamin D provided no benefit to children (not a surprise) – RCT March 2018
- Half the risk of Influenza -A in infants taking 1200 IU of vitamin D for 4 months – RCT Jan 2018
- Vitamin D needed to get children to just 20 ng in winter 800 IU white skin, 1100 IU dark (Sweden) – RCT June 2017
- Third study found that Infants needed 1600 IU of vitamin D – JAMA RCT May 2013
Download the PDF from Vitamin D Life
Neil R. Brett 1, Paula Lavery 1, Sherry Agellon 1, Catherine A. Vanstone 1OrcID, Susan Goruk 2, Catherine J. Field 2OrcID and Hope A. Weiler 1,*
1 School of Human Nutrition, McGill University, 21111 Lakeshore Rd, Ste-Anne-de-Bellevue, Montreal, QC H9X 3V9, Canada
2 Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-126a Li Ka Shing Center for Health Research Innovation, University of Alberta, Edmonton, AB T6G 2E1, Canada
In young children, the relationship between vitamin D and biomarkers of immune function is not well elucidated. The objective was to investigate relationships between vitamin D and immune function in young children. Data were from a cross-sectional study (study 1) of healthy children 1.8–5.9 years (n = 457) and a 12 weeks trial using vitamin D fortified foods (study 2) in healthy 1.8–8.7 years old (n = 77) in Montreal, Canada. Vitamin D status and ex vivo immune function were assessed. In study 1 (male: n = 242; 53%), plasma IL-6, TNFα and CRP were significantly higher (p < 0.05) in children with 25-hydroxyvitamin D (25(OH)D) ≥ 75 nmol/L compared to <50 nmol/L. In study 2 (male: n = 40; 52%), there were no differences in illness outcomes (duration, number of reported illnesses, etc.) among groups. In a 6–8 years old sub-group, only the peripheral blood lymphocytes were higher in the 600 IU/day vitamin D group compared to control (percent of white blood cells; control: 41.6 ± 8.0%, 600 IU/d: 48.6 ± 8.5%). IL-6 production (but not other cytokines) by isolated mononuclear cells, after ex vivo mitogen stimulation, was lower in the intervention groups compared to the control group at 12 weeks.
In conclusion, in healthy young children with sufficient vitamin D status, increasing vitamin D intakes does not confer additional advantage to immune function