Loading...
 
Toggle Health Problems and D

400 IU of Vitamin D provided no benefit to children (not a surprise) – RCT March 2018

Vitamin D status and functional health outcomes in children aged 2–8 y: a 6-mo vitamin D randomized controlled trial

The American Journal of Clinical Nutrition, Volume 107, Issue 3, 1 March 2018, Pages 355–364, https://doi.org/10.1093/ajcn/nqx062
Neil R Brett Colleen A Parks Paula Lavery Sherry Agellon Catherine A Vanstone Martin Kaufmann Glenville Jones Jonathon L Maguire Frank Rauch Hope A Weiler

 Download the PDF from Vitamin D Life

Background: Most Canadian children do not meet the recommended dietary intake for vitamin D.

Objectives: The aims were to test how much vitamin D from food is needed to maintain a healthy serum 25-hydroxyvitamin D3 [25(OH)D3] status from fall to spring in young children and to examine musculoskeletal outcomes.

Design
Healthy children aged 2–8 y (n = 51) living in Montreal, Canada, were randomly assigned to 1 of 2 dietary vitamin D groups (control or intervention to reach 400 IU/d by using vitamin D–fortified foods) for 6 mo, starting October 2014. At baseline and at 3 and 6 mo, anthropometric characteristics, vitamin D metabolites (liquid chromatography–tandem mass spectrometry), and bone biomarkers (IDS-iSYS, Immunodiagnositc Systems; Liaison; Diasorin) were measured and physical activity and food intakes surveyed. At baseline and at 6 mo, bone outcomes and body composition (dual-energy X-ray absorptiometry) were measured. Cross-sectional images of distal tibia geometry and muscle density were conducted with the use of peripheral quantitative computed tomography scans at 6 mo.

Results
At baseline, participants were aged 5.2 ± 1.9 (mean ± SD) y and had a body mass index z score of 0.65 ± 0.12; 53% of participants were boys. There were no differences between groups in baseline serum 25(OH)D3 (66.4 ± 13.6 nmol/L) or vitamin D intake (225 ± 74 IU/d). Median (IQR) compliance was 96% (89–99%) for yogurt and 84% (71–97%) for cheese. At 3 mo, serum 25(OH)D3 was higher in the intervention group (P < 0.05) but was not different between groups by 6 mo. Although lean mass accretion was higher in the intervention group (P < 0.05), no differences in muscle density or bone outcomes were observed.

Conclusions
The consumption of 400 IU vitamin D/d from fall to spring did not maintain serum 25(OH)D3 concentration or improve bone outcomes. Further work with lean mass accretion as the primary outcome is needed to confirm if vitamin D enhances lean accretion in healthy young children.
This trial was registered at www.clinicaltrials.gov as NCT02387892.

Attached files

ID Name Comment Uploaded Size Downloads
9530 400 IU RCT.pdf PDF 2018 admin 17 Mar, 2018 00:39 1.00 Mb 382
See any problem with this page? Report it (FINALLY WORKS)