Profiling of Alzheimer’s disease related genes in mild to moderate vitamin D hypovitaminosis
The Journal of Nutritional Biochemistry. Vol 67, May 2019, Pages 123-137, https://doi.org/10.1016/j.jnutbio.2019.01.015
Note: this study did not apparently consider genes which reduce vitamin D getting to tissues
Alzheimers-Cognition - Overview starts with
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s 21 % more likely if low vitamin D
- FACT: Alzheimer's Disease is 4X less likely if less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: 39 vitamin D and Alz. or Cognition lntervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
- As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
- All items in category Cognition and vitamin D
290 Items in both categories Cognitive and Genetics are listed here:
- Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019
- Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
- 8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019
- Body may change gene activation if more Vitamin D is needed by tissue (Schiz. in this case) – Oct 2018
- Study concluded cognitive problems are not a result of low vitamin D (many studies disagree) Nov 2017
- Genes which reduce blood-level vitamin D increase the risk of Alzheimer’s disease – Dec 2016
- Less vitamin D generated from sunlight by schizophrenia patients – 2016
- Schizophrenia and vitamin D have latitude-related genes – Nov 2010
Items in both categories Cognitive and VitaminD Receptor are listed here:
- Lower vitamin D in blood causes Alzheimer's Disease (Mendelian gene analysis) – Dec 2019
- Cognitive decline not helped by daily vitamin D getting to just 30 ng – RCT July 2019
- Alzheimer’s is associated with all 7 of the genes which restrict vitamin D from getting to tissues – Sept 2018
- Alzheimer’s (1.2X) and Parkenson’s (1.3X) more likely if poor Vitamin D Receptor – meta-analysis March 2019
- Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018
- Body may change gene activation if more Vitamin D is needed by tissue (Schiz. in this case) – Oct 2018
- Alzheimer’s associated with Vitamin D and Vitamin D receptor – video and pdf – Aug 2018
- Cerebral small vessel disease 2.5 X more likely if poor Vitamin D Receptor – Sept 2018
- Alzheimer’s Disease is associated with genes which restrict vitamin D – Aug 2015
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- Alzheimer’s patients are genetically 70 percent more likely to be vitamin D in-efficient – Feb 2012
Download the PDF from Sci-Hub via Vitamin D Life
A vast majority of the elderly population shows a mild to moderate vitamin D deficiency. Besides the well-known function of vitamin D, vitamin D receptor is also expressed in brain and is discussed to regulate several genes. However very little is known whether genes are regulated, associated with Alzheimer’s disease (AD). Here we investigate 117 genes, known to be affected in AD, in mouse brain samples with a mild vitamin D hypovitaminosis comparable to the vitamin D status of the elderly population (20%–30% deficiency). The 117 genes include two positive controls, Nep and Park7, already known to be affected by both AD and vitamin D hypovitaminosis. The 25 most promising candidates were verified in a second independent mouse cohort, resulting in eleven genes further evaluated against three additional housekeeping genes.
Three of the remaining eight significantly altered genes are involved in APP homeostasis- Snca,
- Nep,
- Psmb5),
and each one gene in
- oxidative stress (Park7),
- Inflammation (Casp4),
- lipid metabolism (Abca1),
- signal transduction (Gnb5) and
- neurogenesis (Plat).
Our results tighten the link of vitamin D and AD and underline that vitamin D influences several genes also in brain, highlighting that a strong link not only to AD but also to other neurodegenerative diseases might exist.
8 genes associated with both Alzheimer’s and lowish Vitamin D – May 2019Printer Friendly PDF this page! Follow this page for updates1084 visitors, last modified 10 Dec, 2019, This page is in the following categories (# of items in each category)