Chinese Pre-Print – before peer review Submit Time: 2020-02-26
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Luo, Sihui 1,2 ; Liu, Wei 3 ; Liu, Zhenjun 3 ; Zheng, Xueying 1,2 ; Ling, Ping 1 ; Ding, Yu 1,2 ; Hong, Changxing 3 ; Liu, Zhirong 4 ; Liu, Jian 3 ; Weng, Jianping 1,2,5 ;Institute:
First documented case of an asymptomatic carrier. Wonder how often this occurs.
Recall that one asymptomatic carrier of typhoid was call Typhoid Mary, Should this woman be called Corinna?
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- 1.The First Affiliation Hospital of University of Science and Technology (Anhui Provincial Hospital), Hefei, Anhui 230001, China;
- 2.Institute of Public Health, University of Science and Technology of China, Hefei, Anhui 230026, China.;
- 3.Anqing Hospital Affiliated to Anhui Medical University (Anqing Municipal Hospital), Anqing, Anhui, 246003, China.;
- 4.Anhui Provincial Center for Disease Control and Prevention, Hefei, Anhui 230601, China.;
- 5.Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China;
Here we reported a case of asymptomatic carrier of SARS-CoV-2 infection. A 50-year old woman, lived with her husband in Anqing(Anhui, China) with no significant past medical history, travel history to Wuhan or adjacent area, or exposure to wild animals. She took throat swab test for SARS-CoV-2 nucleic acid due to her husband’s close contact with patients who had SARS-CoV-2 infection.
Her results were confirmed positive on February 6, 2020.
But she did
- not report elevation of temperature measurement,
- nor respiratory or gastrointestinal symptoms and
- her chest CT scan showed no significant abnormalities.
She was hospitalized on February 6 and treated with traditional Chinese medicine(TCM) and antiviral agents. During her hospitalization, apart from a mild elevation of liver enzymes after 10-day treatment of lopinavir/ritonavir and TCM, she was asymptomatic, with her blood cell count, live and renal function largely normal. Her subcutaneous oxygen saturation stayed above 97%. Chest CT scan was repeated on February 11 and 20, and both were negative for signs of viral pneumonia. Notably, a second set of throat swabs and anal swabs were sent to test for SARS-CoV-2 on February 19, and the results were still confirmed positive. This is a confirmed case of asymptomatic carrier of SARS-CoV-2 infection. Her persistent positive findings in both throat and anal swabs suggested the possibility of healthy carrier of the virus, which adds to the difficulty in preventing transmission of the disease.