Vitamin D ameliorates systolic but not diastolic blood pressure in patients with type 2 diabetes: Results from a meta-analysis of randomized controlled trials.
Int J Vitam Nutr Res. 2019 Apr 30:1-10. doi: 10.1024/0300-9831/a000291
Jafari T1,2, Fallah AA3, Rostampour N4, Mahmoodnia L5.
Items in both categories Hypertension and Meta-analyses are listed here:
- Vitamin D does not reduce blood pressure in healthy people (no hypertension, etc) – Meta-analysis Jan 2020
- High Blood Pressure reduced by Vitamin D supplementation in seniors and obese – meta-analysis May 2019
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Hypertension not reduced much if use less than 5,000 IU of Vitamin D – meta-analysis June 2018
- Preeclampsia reduced 2X by Vitamin D, by 5X if also add Calcium – meta-analysis Oct 2017
- Preeclampsia risk reduced 60 percent if supplement with Vitamin D (they ignored dose size) – meta-analysis Sept 2017
- Blood pressure is reduced by more than 800 IU of vitamin D – meta-analysis Aug 2016
- Hypertension is associated with low vitamin D in some groups – meta-analysis April 2015
- Hypertension reduced by Omega-3, especially if previously untreated – meta-analysis July 2014
- Probiotics reduces blood pressure, but not as much as vitamin D does – meta-analysis July 2014
- Hypertension associated with genes which reduce vitamin D – meta-analysis June 2014
- Preeclampsia rate cut in half by high level of vitamin D – meta-analysis March 2014
- Preeclampsia 2.7X more frequent if low vitamin D – meta-analysis Sept 2013
- 2X more preeclampsia when vitamin D less than 30 ng, etc. - meta-analysis March 2013
- Hypertension 30 percent more likely if low vitamin D – meta-analysis March 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Vitamin D associated with 50 percent less ischemic stroke – meta-analysis Aug 2012
- Hypertension 2X more likely when vitamin D levels lower than 14 ng – meta-analysis May 2012
- Meta-analysis found hypertension reduced with vitamin D – Dec 2010
Items in both categories Hypertension and Diabetes are listed here:
- COVID-19 deaths 4 to 7 X more likely if Diabetic, Hypertensive, or CVD - meta-analysis March 2020
- Vitamin D reduced only the systolic blood pressure in T2DM – Meta-analysis April 2019
- Upsurge in Metabolic diseases may be due to low vitamin D – May 2016
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- Blood pressure in diabetics reduced by 12 weekly doses of 50,000 IU vitamin D – RCT Jan 2014
- Hypothesis- Metabolic disease is due to Tissue Renin-Angiotensin Systems – Feb 2014
- During pregnancy even 400 IU helps metabolic status – RCT July 2013
- Metabolic Syndrome in children is associated with low vitamin D – review Jan 2013
- Pre-diabetes and hypertension 2.4X more common when less than 30 ng of vitamin D – Jan 2011
Inconsistent findings have been reported regarding the effects of vitamin D on blood pressure in patients with type 2 diabetes (T2D). This study aimed to evaluate the subject through a meta-analysis. A computerized literature search on five databases was performed and randomized controlled trials (RCTs) published until March 2016 were identified. The eligibility criteria for articles to be selected were parallel-group RCTs in which consumption of a kind of vitamin D was compared with placebo in patients with T2D. Un-standardized mean difference and its corresponding 95 % confidence interval (CI) was calculated from the effect sizes by using random effects model. Studies comparing intervention group (received vitamin D) with control group (received placebo) were enrolled in meta-analysis.
Meta-analysis on 26 studies with 1789 type 2 diabetic subjects showed that vitamin D significantly
- reduced systolic blood pressure (SBP; -0.97 mmHg, 95 % CI: -1.94, -0.001, P = 0.050), but
- not diastolic blood pressure (DBP; -0.10 mmHg, 95 % CI: -0.22, 0.02, P = 0.087).
Subgroup analyses showed that administration of vitamin D in patients with baseline serum 25-hydroxyvitamin D < 50 nmol/l and baseline SBP < 140 mmHg significantly reduced SBP. Moreover, the patients who received vitamin D without Ca co-supplementation showed significant reduction in SBP. Vitamin D doses (< 2000 or > 2000 IU/ day) and method of vitamin D application (Supplementation or food fortification) did not affect the blood pressure. This study demonstrated that vitamin D improved SBP in type 2 diabetic patients. Therefore, this vitamin can be considered as an adjuvant therapy in these patients.