Vitamin D Life Summary
Vitamin D may be able to treat many multidrug-resistant diseases
Cells which pump drugs out of them have the protein MRP1
Calcitriol kills cells with MRP1 (in Petrie dish)
This may be the reason that Vitamin D helps Chemo, etc.
How vitamin D helps fight treatment-resistant cancer Medical News Today
- “The researchers showed that calcitriol and calcipotriol can selectively hone in on cancer cells that have too much MRP1 and destroy them”
- “… multidrug resistance-associated protein 1 (MRP1). The protein sits in the cell wall and drives a pump that ejects cancer drugs out of the cell.”
- “Cancer cells that develop resistance to chemotherapy drugs often overexpress, or overproduce, transporter proteins. This abundance is the primary cause of chemoresistance”
- “MRP1 doesn't just reduce the effectiveness of cancer drugs, it can also weaken the effect of antibiotics, antivirals, anti-inflammatories, antidepressants, and drugs that treat HIV.”
Reference
Calcitriol and Calcipotriol Modulate Transport Activity of ABC Transporters and Exhibit Selective Cytotoxicity in MRP1-overexpressing Cells
Kee W. Tan, Angelina Sampson, Bremansu Osa-Andrews and Surtaj H. Iram
Drug Metabolism and Disposition December 2018, 46 (12) 1856-1866; DOI: https://doi.org/10.1124/dmd.118.081612
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MRP1 connection may explain many of the following
- Chemotheraphy not work as well with low Vitamin D (colon cancer this time) – Aug 2018
- Chemotherapy drugs often reduce Vitamin D levels, restoring levels helps– Aug 2018
- Breast cancer reoccurred twice as often if have less than 20 ng of vitamin D – Dec 2018
- Breast Cancer chemotherapy 2.7 X more likely to be successful if not vitamin D deficient – Dec 2017
- Recurrence of head and neck cancer reduced by half in those getting more vitamin D (in food) – May 2018
- Cancer treatment helped by Vitamin D, C, and E – Book 2017
- Chemotherapy might be augmented with Vitamin D – Jan 2017
Calcitriol in Vitamin D Life
- Calcitriol category listing has
46 items along with related searches - Active vitamin D appears to treat cancer – more studies needed – June 2018
Quick Chemo look on the web
Known Half of late-stage cancer patients get chemotherapy Unknown % of Cancers which are now Chemo resistant Vitamin D fights treatment-resistant cancers (petrie dish) – June 2019Printer Friendly PDF this page! Follow this page for updates1824 visitors, last modified 20 Jun, 2019,