Vitamin D can also fight COVID induced brain problems (behind paywall) – April 2022

Vitamin D and its possible relationship to neuroprotection in COVID-19: evidence in the literature

Curr Top Med Chem. 2022 Apr 1. doi: 10.2174/1568026622666220401140737 $95
Saray Quintero-Fabián 1, Cindy Bandala 2 3, Luz Adriana Pichardo-Macías 4, Itzel Jatziri Contreras-García 5, Saúl Gómez-Manzo 6, Beatriz Hernández-Ochoa 7, José Arturo Martínez-Orozco 8, Iván Ignacio-Mejía 1, Noemí Cárdenas-Rodríguez 9

Vitamin D is a hormone involved in the regulation of important biological processes such as signal transduction, immune response, metabolic regulation and also in the nervous and vascular systems. To date, coronavirus disease 2019 (COVID-19) infection does not have a specific treatment, however various drugs have been proposed, including those that attenuate the intense inflammatory response and recently the use of vitamin D, in clinical trials, as part of the treatment of COVID-19 has provided promising results. It has been observed in some clinical studies that the use of cholecalciferol (vitamin D3) and its two metabolites the circulating form, calcidiol or calcifediol (25-hydroxycalciferol, 25-(OH)-D) and the active form, calcitriol (1,25-(OH)2-D), in different doses, improve the clinical manifestations, prognosis and survival of patients infected with COVID-19 probably because of its anti-inflammatory, antiviral and lung-protective action.

In relation to the central nervous system (CNS) it has been shown, in clinical studies, that vitamin D is beneficial in some neurological and psychiatric conditions because of its anti-inflammatory and antioxidant properties, modulation of neurotransmitters actions, regulation of calcium homeostasis between other mechanisms. It has been showed that COVID-19 infection induces CNS complications such as

• headache,
• anosmia,
• ageusia,
• neuropathy,
• encephalitis,
• stroke,
• thrombosis,
• cerebral hemorrhages,
• cytotoxic lesions and
• psychiatric conditions

and it has been proposed that the use of dietary supplements, as vitamin and minerals, can be adjuvants in this disease. In this review the evidence of possible role of vitamin D, and its metabolites, as protector against the neurological manifestations of COVID-19 was summarized.

10 studies in both Virus and Cognitive

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4 studies in both Virus and Parkinson's Disease categories

Vitamin D Life – COVID-19 treated by Vitamin D - studies, reports, videos

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