Vitamin D and Age-Related Macular Degeneration
Nutrients 2017, 9(10), 1120; doi:10.3390/nu9101120, 13 October 2017
Alfredo Garcia Layana 1,* , Angelo Maria Minnella 2OrcID, Gerhard Garhöfer 3, Tariq Aslam 4,5OrcID, Frank G. Holz 6, Anita Leys 7, Rufino Silva 8,9,10,11OrcID, Cécile Delcourt 12, Eric Souied 13 and Johanna M. Seddon 14,15
- Male late stage Age-Related Macular Degeneration is strongly associated with low vitamin D – July 2014
- Wet AMD 3X less likely if high level of vitamin D – June 2014
- Late stage AMD 2.2 more likely if low vitamin D – meta-analysis April 2016
- Vitamin D may help prevent macular degeneration in women younger than 75 – April 2011
- Off topic: Baby-sized aspirin doubles chance of getting wet macular degeneration
- Macular degeneration 4X more likely if low vitamin D and a particular gene – May 2013
- Macular Degeneration decreased with UV and perhaps Vitamin D genetics– Oct 2011
- Macular Degeneration Twin Study – Vitamin D reduced, smoking increased (by 13X in later study)
- Age-Related Macular Degeneration - Diet, bionome, Vitamin D, CBD, Avastin, etc
Vision category starts with the following
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- Vitamin D treats and prevents a variety of eye problems (need 70 ng) – June 2018
- Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015
- Myopia may be related to low vitamin D
- Tears often have 25 % higher levels of vitamin D than does blood
- Cataracts prevented and perhaps treated by Vitamin D - 2015
- All people with Cataracts had low vitamin D levels – April 2019
- Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017
- Vitamin D is the best vitamin to fight glaucoma – May 2018
See also web
- The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review April 2016; Free PDF online
9% decreased risk for each 10 ng increase in Vitamin D levels in blood - result was not statistically significant (p=.12) - Circulating vitamin D concentration and age-related macular degeneration: Systematic review and meta-analysis June 2016
AMD was inversely associated with the highest 25OHD quintile compared with the lowest (summary odds ratio (OR)=0.83
late AMD OR=0.47; doi: 10.1016/j.maturitas.2016.04.002 - Serum 25-Hydroxyvitamin D Concentrations and Incidence of Age-Related Macular Degeneration - April 2019
- 2X reduction in getting AMD in those with > 30 ng of vitamin D
doi: 10.1167/iovs.18-2594 FREE PDF online
AMD expected to increase about 30% in a decade (adjusted for age)
The estimated prevalence and incidence of late stage age related macular degeneration in the UK
British Journal of Ophthalmology 2012;96:752-756
Download the PDF from Vitamin D Life
13X higher risk of AMD if smoke 20 pack years (i.e. 2 packs a day for 10 years)
- Incidence of and Risk Factors Associated With Age-Related Macular Degeneration: Four-Year Follow-up From the ALIENOR Study
May 2018, doi: 10.1001/jamaophthalmol.2018.0504.
Download the PDF from Vitamin D Life
Download the PDF from Vitamin D Life
In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.
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| ID | Name | Comment | Uploaded | Size | Downloads | |
|---|---|---|---|---|---|---|
| 11563 | AMD 20 pack years.pdf | PDF 2018 | admin 15 Mar, 2019 00:36 | 242.05 Kb | 205 | |
| 11556 | AMD UK.pdf | admin 14 Mar, 2019 22:40 | 230.27 Kb | 160 | ||
| 11555 | Late AMD 10 years.jpg | admin 14 Mar, 2019 22:39 | 30.54 Kb | 401 | ||
| 9212 | AMD.pdf | PDF 2017 | admin 18 Jan, 2018 10:52 | 1.13 Mb | 321 |