THE ROLE OF VITAMIN D AND VDR IN CARCINOGENESIS: THROUGH EPIDEMIOLOGY AND BASIC SCIENCES.
J Steroid Biochem Mol Biol. 2016 Nov 29. pii: S0960-0760(16)30337-5. doi: 10.1016/j.jsbmb.2016.11.020. [Epub ahead of print]
Bandera Merchan B1, Morcillo S2, Martin-Nuñez G1, Tinahones FJ3, Macías-González M4.
- High PSA readings with Prostate Cancer 4 times more likely if poor Vitamin D receptor – March 2016
- Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
- Increased Breast Cancer metastasis if low vitamin D or poor VDR – Feb 2016
- Skin cancer 20 percent more likely with some Vitamin D receptor gene polymorphisms – Oct 2015
- Poor Bladder Cancer survival associated with poor Vitamin D receptor – Oct 2015
- Increased risk of some female cancers if low vitamin D (due to genes) – meta-analysis June 2015
- Pancreatic Cancer massively deregulates the local Vitamin D receptors and CPY24A1 – July 2014
- Vitamin D receptor polymorphisms are risk factors for various cancers – meta-analysis Jan 2014
Vitamin D Receptor category has the following
Vitamin D tests cannot detect Vitamin D Receptor (VDR) problems
A poor VDR restricts Vitamin D from getting in the cells
It appears that 30% of the population have a poor VDR (40% of the Obese )
A poor VDR increases the risk of 55 health problems click here for details
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
VDR at-home test $29 - results not easily understood in 2016
There are hints that you may have inherited a poor VDR
Compensate for poor VDR by increasing one or more:
| Increasing | Increases |
| 1) Vitamin D supplement Sun, Ultraviolet -B | Vitamin D in the blood and thus in the cells |
| 2) Magnesium | Vitamin D in the blood AND in the cells |
| 3) Omega-3 | Vitamin D in the cells |
| 4) Resveratrol | Vitamin D Receptor |
| 5) Intense exercise | Vitamin D Receptor |
| 6) Get prescription for VDR activator paricalcitol, maxacalcitol? | Vitamin D Receptor |
| 7) Quercetin (flavonoid) | Vitamin D Receptor |
| 8) Zinc is in the VDR | Vitamin D Receptor |
| 9) Boron | Vitamin D Receptor ?, etc |
| 10) Essential oils e.g. ginger, curcumin | Vitamin D Receptor |
| 11) Progesterone | Vitamin D Receptor |
| 12) Infrequent high concentration Vitamin D Increases the concentration gradient | Vitamin D in the cells |
| 13) Sulfroaphone and perhaps sulfur | Vitamin D Receptor |
Note: If you are not feeling enough benefit from Vitamin D, you might try increasing VDR activation. You might feel the benefit within days of adding one or more of the above
Far healthier and stronger at age 72 due to supplements Includes 6 supplements which help the VDR
In the last two decades vitamin D (VD) research has demonstrated new extraskeletal actions of this pre-hormone, suggesting a protective role of this secosteroid in the onset, progression and prognosis of several chronic noncommunicable diseases, such as cardiovascular disease, diabetes mellitus or cancer. Regarding carcinogenesis, both preclinical and epidemiological evidence available show oncoprotective actions of VD and its receptor, the VDR.
However, in late neoplastic stages the VD system (VDS) seems to be less functional, which appears to be due to an epigenetic silencing of the system. In preclinical experimental studies, VD presents oncoprotective actions through
- modulation of inflammation,
- cell proliferation,
- cell differentiation,
- angiogenesis,
- invasive and metastatic potential,
- apoptosis,
- miRNA expression regulation and
- modulation of the Hedgehog signalling pathway.
Moreover, epidemiological evidence points towards an oncoprotective role of vitamin D and VDR in colorectal cancer. This association is more controversial with breast, ovarian and prostate cancers, although with a few adverse effects. Nonetheless, we should consider other factors to determine the benefit of increased serum concentration of VD.
Much of the epidemiological evidence is still inconclusive, and we will have to wait for new, better-designed ongoing RCTs and their results to discern the real effect of vitamin D in cancer risk reduction and therapy.
The objective of this literature review is to offer an up-to-date analysis of the role of the VD and VDR, in the onset, progression and prognosis of all types of cancer. We further discuss the available literature and suggest new hypotheses and future challenges in the field of VD research.
PMID: 27913313 DOI: 10.1016/j.jsbmb.2016.11.020 Publisher wants $40 for the 56 page preliminary PDF
from PDF
“Finally, let’s face the $64,000 question: is vitamin D deficiency the cause of
disease or is disease the culprit of vitamin D deficiency? The author tends to
think that, due to the inclusive rather than exclusive essence of nature, both
propositions are correct. “
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