J Infect Dev Ctries. 2015 Jan 15;9(1):8-19. doi: 10.3855/jidc.3687.
Khanh Vinh Quốc Luong, Lan Thi Hoàng Nguyen
Vietnamese American Medical Research Foundation, Westminster, California, United States. lng2687765 at aol.com.
An abnormal calcium-parathyroid hormone (PTH)-vitamin D axis has been reported in patients with malaria infection. A role for vitamin D in malaria has been suggested by many studies. Genetic studies have identified numerous factors that link vitamin D to malaria, including human leukocyte antigen genes, toll-like receptors, heme oxygenase-1, angiopoietin-2, cytotoxic T lymphocyte antigen-4, nucleotide-binding oligomerization domain-like receptors, and Bcl-2. Vitamin D has also been implicated in malaria via its effects on the Bacillus Calmette-Guerin (BCG) vaccine, matrix metalloproteinases, mitogen-activated protein kinase pathways, prostaglandins, reactive oxidative species, and nitric oxide synthase.
Vitamin D may be important in malaria; therefore, additional research on its role in malaria is needed.
In this paper, the relationship between vitamin D and malaria was reviewed. Genetic studies provide opportunities to determine which proteins link vitamin D to malaria pathology. Vitamin D is able to act through numerous non-genomic mechanisms, including protein expression, oxidative stress, inflammation, and cellular metabolism. Therefore, further research on the role of vitamin D in malaria is needed, and a cautious approach is advisable before recommending the widespread use of vitamin D for malaria.
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A, B, C, D, E
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