Loading...
 
Toggle Health Problems and D

The Anti-cancer Actions of Vitamin D – Jan 2013

Anti-Cancer Agents in Medicinal Chemistry Volume 13 Issue 1 pp.126-139 (14)
Authors: Kun-Chun Chiang, Tai C. Chen

Vitamin D3 is biologically inert. To become active, it requires two successive hydroxylation steps catalyzed by two cytochrome P450 enzymes, first to synthesize the pro-hormone 25-hydroxyvitamin D3 [25(OH)D3] and then the active hormone 1α,25- dihydroxyvitamin D3 [1α,25(OH)2D3]. 1α,25(OH)2D3 has high affinity for the vitamin D receptor (VDR), a transcription factor and a member of the steroid receptor superfamily. Through VDR, 1α,25(OH)2D3 regulates more than 200 genes in mammals, including those involved in the calcium and phosphorus homeostasis, immune function, reproduction, cardiovascular, central nerve system, inflammation, angiogenesis, and cellular proliferation, differentiation and apoptosis. Due to its versatile roles in maintaining and regulating normal cellular phenotypes and functions, 1α,25(OH)2D3 has been implicated as an anti-cancer agent. In fact, ecological and epidemiologic data have linked vitamin D deficiency with the incidence and mortality of many types of cancer. More importantly, in vitro and in vivo animal model studies have clearly demonstrated the anti-tumor effects of vitamin D. In this review, we describe the anticancer actions of vitamin D, with special emphasis on different pathways underlying the VDR-mediated genomic as well as less-defined non-genomic actions of vitamin D.

Affiliation: Boston University School of Medicine, M-1022, 85 E. Newton Street, Boston, MA 02118 USA.

Figure F3

Image
PDF is attached at the bottom of this page


See also Vitamin D Life

Attached files

ID Name Comment Uploaded Size Downloads
1784 Anti-cancer actions.pdf PDF admin 06 Dec, 2012 04:44 937.89 Kb 1102
1783 Anti-cancer F3.jpg admin 06 Dec, 2012 04:42 52.62 Kb 9273
See any problem with this page? Report it (FINALLY WORKS)