Table of contents
- Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes: A Prospective Study
- Vitamin D Life - Overview Diabetes and vitamin D contains
- Vitamin D Life -
24 studies in both categories Diabetes and Vitamin D Receptor - The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019
- Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
- Vitamin D Life -
5 studies in both categories Diabetes and Vitamin D Binding (GC) - Vitamin D Life Diabetes pages with NEUROPATHY in title (14 as of Aug 2022)
Vitamin D Status, Vitamin D Receptor Polymorphisms, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes: A Prospective Study
Diabetes Care. 2022 Sep 28;dc220513. soi: 10.2337/dc22-0513
Xue Chen 1 , Zhenzhen Wan 1 , Tingting Geng 1 , Kai Zhu 1 , Rui Li 1 , Qi Lu 1 , Xiaoyu Lin 1 , Sen Liu 1 , Liangkai Chen 1 , Yanjun Guo 2 , Zhilei Shan 1 , Liegang Liu 1 , An Pan 3 , JoAnn E Manson 4 5 6 , Gang Liu 1Objective: Evidence is limited regarding the associations between vitamin D status and microvascular complications in individuals with type 2 diabetes (T2D), among whom vitamin D deficiency or insufficiency is particularly common. In this study we aimed to prospectively investigate the associations of serum 25-hydroxyvitamin D []25(OH)D] and vitamin D receptor (VDR) polymorphisms with risk of diabetic microvascular complications.
Research design and methods: This analysis included 14,709 participants with T2D who were free of microvascular complications from the UK Biobank. Incidence of diabetic microvascular complications was ascertained via electronic health records. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% CIs.
Results: Median serum 25(OH)D concentration was 40.7 nmol/L (interquartile range 27.5, 56.4). During a median of 11.2 years of follow-up, 1,370 people developed diabetic microvascular complications.
Compared with participants with 25(OH)D <25 nmol/L, individuals with 25(OH)D ≥75 nmol/L had a multivariable-adjusted HR of- 0.65 (95% CI 0.51, 0.84) for composite diabetic microvascular complications,
- 0.62 (0.40, 0.95) for diabetic retinopathy,
- 0.56 (0.40, 0.79) for diabetic nephropathy, and
- 0.48 (0.26, 0.89) for diabetic neuropathy.
In addition, in comparisons with participants with 25(OH)D <25 nmol/L and minor allele homozygotes (TT of rs1544410 and GG of rs731236), the multivariable-adjusted HRs of composite diabetic microvascular complications were 0.54 (0.38, 0.78) and 0.55 (0.38, 0.80) for participants with serum 25(OH)D ≥50 nmol/L and major allele homozygotes (CC and AA), respectively, although no significant interaction was observed.
Conclusions: Higher serum 25(OH)D concentrations were significantly associated with lower risk of diabetic microvascular complications, including diabetic retinopathy, diabetic nephropathy, and diabetic neuropathy. Our findings suggest a potential beneficial role of maintaining adequate vitamin D status in the prevention of diabetic microvascular complications.
Download the PDF from Vitamin D LifeThis study incorrectly assumes that Vitamin D levels will not change in 11 years
Vitamin D Life - Overview Diabetes and vitamin D contains
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
537 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- 90% less T2 Diabetes in the group having lots of Vitamin D
- Appears that Magnesium helps both Prevention and Treatment
- Many diabetics would be better treated if Gut-Friendly Vitamin D were used
Number of articles in both categories of Diabetes and:
'This list is automatically updated''- Dark Skin
24 ; Intervention 56 ; Meta-analysis 38 ; Obesity 35 ; Pregnancy 44 ; T1 (child) 39 ; Omega-3 11 ; Vitamin D Receptor 24 ; Genetics 12 ; Magnesium 27 Click here to see details Some Diabetes studies
- Type 2 Diabetes treated by Vitamin D (often 50,000 IU weekly) – meta-analysis July 2023
- Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Diabetes helped somewhat by weekly 50,000 IU of vitamin D (5 ways to improve) – RCT Aug 2021
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
T1 Diabetes
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
Pre-Diabetes
- 4X reduction in prediabetes progressing to T2D if more than 50 ng of vitamin D – RCT March 2023
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
Diabetes, Metabolic Syndrome and Magnesium - many studies
Diabetic Epidemic
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Vitamin D Life -
24 studies in both categories Diabetes and Vitamin D Receptor This list is automatically updated
- T2 Diabetes might be fought by Vitamin D plus Vitamin D Receptor activators – April 2023
- Diabetes 3X more likely if had COVID ICU (VDR was deactivated) - April 2023
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- T2 Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- Gestational Diabetes – increased risk if poor Vitamin D Receptor – 2 Meta-Analyses 2021
- Type 1 Diabetes (Autoimmune) and Vitamin D, Vitamin D Receptor and Cathelicidin - Dec 2020
- Diabetes decreased by activating Vitamin D Receptor (transgenic mice) – Feb 2020
- Gestational Diabetes 2.4X more likely if poor Vitamin D Receptor (region in China) – June 2019
- Gestational Diabetes 3 X more likely if poor Vitamin D receptor (Turkey) – May 2019
- Resveratrol prevented bone loss associated with T2DM (probably via VDR) – RCT Sept 2018
- Diabetic nephropathy deactivates the Vitamin D Receptor, reducing tissue Vit D – Feb 2019
- Resveratrol improves health (Vitamin D receptor, etc.)
- Inflammation and immune responses to Vitamin D (perhaps need to measure active vitamin D) – July 2017
- Type 1 Diabetes 14 percent more likely with 2 Vitamin D Receptor mutations – Oct 2017
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Type 1 Diabetes association with poor Vitamin D Receptor: 39 studies – April 2017
- Type 1 diabetes 1.6 times more likely if a Vitamin D Receptor problem – Feb 2017
- Diabetic Retinopathy 2 X more likely if poor Vitamin D Receptor – meta-analysis Nov 2016
- Diabetic foot ulcer 1.7 times more likely if poor Vitamin D Receptor – Jan 2017
- Vitamin D activates the hypothalamus (in rodents) to reduce weight and diabetes– May 2016
- Diabetes (T2) 16 percent more likely if Vitamin D receptor problem – Oct 2015
- Type 1 diabetes associated with faulty Vitamin D receptor genes – May 2013
- Vitamin D receptor gene associated with 50 percent more type 2 Diabetes – meta-analyses 2013, 2016
The risk of 44 diseases at least double with poor Vitamin D Receptor as of Oct 2019__
Vitamin D Life - Vitamin D Receptor activation can be increased in many ways
Resveratrol, Omega-3, Magnesium, Zinc, Quercetin, non-daily Vit D, Curcumin, Berberine, intense exercise, Butyrate Sulforaphane Ginger, Essential oils, etc Note: The founder of Vitamin D Life uses 10 of the 16 known VDR activators
Vitamin D Life -
5 studies in both categories Diabetes and Vitamin D Binding (GC) This list is automatically updated
- T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022
- T1 Diabetes 6.5 X more likely in South African Blacks if poor Vitamin D Binding Protein – July 2022
- Type 1 Diabetes risk increased if high postpartum Vitamin D binding protein – Jan 2019
- Gestational Diabetes Mellitus associated with 4 Vitamin D genes – Oct 2015
- Type 1 diabetes patients may be pissing away vitamin D – Jan 2011
Vitamin D Life Diabetes pages with NEUROPATHY in title (14 as of Aug 2022)
This list is automatically updated
Items found: 14T2 diabetes complications increased 35-52 percent if low vitamin D – Sept 2022(Cached) Printer Friendly Follow this page for updates1369 visitors, last modified 05 Jan, 2024, This page is in the following categories (# of items in each category)