- Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy
- Vitamin D Life – Overview Breast Cancer and Vitamin D contains:
- Vitamin D Life – Overview Obesity and Vitamin D contains:
- Obese and Dark Skin have a similar risk of Vitamin D Deficiency
Post-diagnosis serum 25-hydroxyvitamin D concentrations in women treated for breast cancer participating in a lifestyle trial in Italy
Reumatismo 2024 Mar 22;76(1). doi: 10.4081/reumatismo.2024.1632 Italy
Risks for those not supplementing with Vitamin D
| BMI | Risk of <20 ng vs <25 kg/m2 |
| 25-30 | 2.68 X |
| >30 | 5.38 X |
| ≥35 | 7.08 X |
Objective: To report cross-sectionally serum levels of 25-hydroxyvitamin D [25(OH)D] in women living in Italy within 12 months from breast cancer (BC) diagnosis.
Methods: Baseline data were obtained from 394 women diagnosed with primary BC, enrolled from 2016 to 2019 in a lifestyle trial conducted in Italy. Subjects' characteristics were compared between two 25(OH)D concentrations (hypovitaminosis D<20 and ≥20 ng/mL) with the Chi-squared test or Fisher's exact test for small-expected counts. Using multiple logistic regression-adjusted models, we estimated odds ratios (ORs) of hypovitaminosis D with 95% confidence intervals (CIs) in the total sample and in the unsupplemented subgroup.
Results: Hypovitaminosis D was found in 39% of all subjects, 60% in unsupplemented subjects, and 10% in supplemented subjects. Increasing ORs of hypovitaminosis D were found with increasing body mass index, 25-30, >30, and ≥35 versus <25 kg/m2 (ORs: 2.50, 4.64, and 5.81, respectively, in the total cohort and ORs: 2.68, 5.38, and 7.08 in the unsupplemented); living in the most southern Italian region (OR 2.50, 95%CI 1.22-5.13); and with hypertriglyceridemia (OR 2.46; 95%CI 1.16-5.22), chemotherapy history (OR 1.86, 95%CI 1.03-3.38), and inversely with anti-estrogenic therapy (OR 0.43, 95%CI 0.24-0.75) in the total sample.
Conclusions: Hypovitaminosis D in women recently diagnosed with BC and participating in a lifestyle trial in Italy was widespread and highest with obesity, hypertriglyceridemia, and chemotherapy use. Considering that hypovitaminosis D is a risk factor for lower efficacy of bone density treatments and possibly BC mortality, our results suggest the need to promptly address and treat vitamin D deficiency.
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Vitamin D Life – Overview Breast Cancer and Vitamin D contains:
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24 Meta-analyses of Vitamin D and Breast Cancer
example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
wonder just how much more proof is needed- Breast Cancer 4X more likely if have poor genes
- Cancer - Breast category listing has
252 items along with related searches - Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
- Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
- Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
- Vitamin D both prevents and treats Breast Cancer – 2019
Vitamin D Life – Overview Obesity and Vitamin D contains:
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc. - Obesity category has
428 items See also: Weight loss and Vitamin D - many studies Child Obesity and Vitamin D - many studies Obese need more Vitamin D
- Normal weight Obese (50 ng = 125 nanomole)
Obese and Dark Skin have a similar risk of Vitamin D Deficiency
Vitamin D Life -22 studies in both categories Obesity and Dark Skin This list is automatically updated
- Predictors of low vitamin D: race, age, and BMI (confirmed now by Machine Learning) – Feb 2024
- Cancer of breast is highest in dark-skinned women (low Vitamin D: dark skin and obese) - Feb 2022
- Sarcopenia with obesity is more likely if dark skin, diabetes, OR COPD (all associated with low vitamin D)
- 26 health factors increase the risk of COVID-19 – all are proxies for low vitamin D
- Half of obese black teens achieved at least 30 ng of Vitamin D with 5,000 IU daily – June 2018
- Stroke outcome 6.9 X worse if black and overweight (all three related via low vitamin D) – March 2018
- Indoor pollution is a problem with obese black asthmatic children – May 2018
- Blacks are more obese, have lower Vitamin D, and have more Cancer etc. than whites – Feb 2018
- Increase in Vitamin D deficiency with weight and skin darkness – chart – March 2016
- 5,000 IU daily or 50,000 IU Vitamin D weekly repleted many dark skinned adolescents – RCT Dec 2015
- Obese diabetics with dark skins not benefit from 6,000 IU of vitamin D daily (no surprise) – RCT March 2015
- African-Americans at high risk of obesity and diabetes - 2011
- Bariatric surgery less than 30 ng of vitamin D – 82 pcnt teens, 100 pcnt of black teens – June 2012
- Low vitamin D associated with obesity-related diseases for ethnic minorities – Sept 2011
- Reasons for low response to vitamin D
- Telomeres improved when obese blacks took 2000 IU of vitamin D daily – Oct 2011
- Black women lacking Calcium and Vitamin D weighed more – Aug 2011
- Dark skinned obese not helped much by weekly 50000 IU dose of vitamin D – May 2011
- Black obese children had low vitamin D and more fat under skin than whites – Mar 2011
- Obesity in American-Indians and African-American teens
- Vitamin D3 in obese and non obese African American children – 2008
- Low vitamin D in teens: especially black or overweight – June 2010
Risk of Vitamin D deficiency with Breast Cancer: 2.7 X if normal weight, 7 X if obese (no surprise) – March 2024Printer Friendly Follow this page for updates95 visitors, last modified 26 Mar, 2024, This page is in the following categories (# of items in each category)
- Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer