Immune Response: A Missed Opportunity Between Vitamin D and Radiotherapy
Review Front Cell Dev Biol . 2021 Apr 13;9:646981. doi: 10.3389/fcell.2021.646981
Xinyue Yu 1, Baocai Liu 1, Ning Zhang 1, Qian Wang 1, Guanghui Cheng 1
As with Chemotherapy, may need to reduce the amount of radiation therapy when Vitamin D levels are increased
click on chart for details
- Less radiation therapy needed if have more vitamin D (lung cancer in lab) – March 2017
- Vitamin D prevents and treats cancer in many ways – May 2021
- Vitamin D and breast cancer radiation - with observations on vitamin D and radiation therapy
- 3X less pelvic inflammation from cancer radiation if high level of vitamin D – Feb 2015
Note: To be of a benefit, Vitamin D levels need to be raised BEFORE radiation therapy
A large vitamin D loading dose can restore Vitamin D levels in 10 days
Loading Dose of Vitamin D category has the following
see also Overview Loading of vitamin D Overview Toxicity of vitamin D
Injection category listing has
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of adverse reactions
Many studies report on the benefits resulting from loading doses
The TOP articles in Loading Dose of Vitamin D are listed here:
- Vitamin D loading dose (stoss therapy) proven to improve health
- Low trauma bone fractures in seniors – considering Vitamin D loading dose for all, without testing – Nov 2019
- Intensive Care (ICU) helped by Vitamin D – review of past and on-going studies – Dec 2018
- Vitamin D restoration then monthly was the most popular dosing by trials – Nov 2018
- Rickets virtually cured by 90,000 IU of Vitamin D along with daily Calcium – RCT Nov 2018
- Rapidly restore Vitamin D levels with 10,000 IU per kg for children in ICU – RCT 2024
- Reasons for Low Vitamin D and what to do
- Vitamin D could be restored in 60 days (actually much faster) – June 2018
- Healthy in Seven Days - Loading dose of Vitamin D – book 2014
Download the PDF from Vitamin D Life
Radiotherapy (RT) is a mainstay treatment in several types of cancer and acts by mediating various forms of cancer cell death, although it is still a large challenge to enhance therapy efficacy. Radiation resistance represents the main cause of cancer progression, therefore, overcoming treatment resistance is now the greatest challenge for clinicians. Increasing evidence indicates that immune response plays a role in reprogramming the radiation-induced tumor microenvironment (TME). Intriguingly, radiation-induced immunosuppression possibly overwhelms the ability of immune system to ablate tumor cells. This induces an immune equilibrium, which, we hypothesize, is an opportunity for radiosensitizers to make actions.
Vitamin D has been reported to act in synergistic with RT by potentiating antiproliferative effect induced by therapeutics. Additionally, vitamin D can also regulate the TME and may even lead to immunostimulation by blocking immunosuppression following radiation. Previous reviews have focused on vitamin D metabolism and epidemiological trials, however, the synergistic effect of vitamin D and existing therapies remains unknown.
This review summarizes vitamin D mediated radiosensitization, radiation immunity, and vitamin D-regulated TME, which may contribute to more successful vitamin D-adjuvant radiotherapy.
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