Hypovitaminosis D is Associated with Psoriasis: A Systematic Review and Meta-Analysis.
Kans J Med. 2019 Nov 25;12(4):103-108. eCollection 2019 Nov.
Pitukweerakul S1, Thavaraputta S2, Prachuapthunyachart S3, Karnchanasorn R1.
(35,000 IU vitamin D daily for 6 months helped ALL psoriasis suffers (106 ng) – Brazil March 2013
Items in both categories Psorasis and Meta-analysis:
- Psoriasis is associated with 6 ng less vitamin D – meta-analysis Nov 2019
- Psoriasis risk in Caucasians is 1.3 X higher if poor Vitamin D Receptor – meta-analysis Nov 2018
- Psoriasis severity associated with low vitamin D (10 studies) – meta-analysis Jan 2018
- Psorasis treatment helped by Vitamin D – Cochrane March 2013
- Vitamin D plus steroids helps psoriasis 2X more than vitamin D – meta-analysis May 2012
- Psoriasis best treated by combinations such as vitamin D and UVB – meta-analysis Dec 2011
INTRODUCTION:
Psoriasis is a chronic inflammatory and immune-mediated skin disease that affects over 7.2 million U.S. adults. Current treatment has improved clinical outcomes. Vitamin D is believed to affect the proliferation and regeneration of keratinocytes; therefore, its deficiency is a possible risk factor; however, there is still no definite evidence. The objective of this study was to synthesize existing data on the relationship between hypovitaminosis D and psoriasis.
METHODS:
A meta-analysis of relevant studies was conducted by doing a comprehensive search in the MEDLINE, EMBASE, and the Cochrane Central Register through July 2018 to identify relevant cohort studies and to assess serum 25-hydroxyvitamin D (25(OH)D) levels in adults with psoriasis. The primary outcome was the mean difference in serum 25(OH)D level between psoriatic patients and controls.
RESULTS:
The initial search identified 107 articles. Only ten studies met the criteria for full-paper review. Meta-analysis was conducted from ten prospective cohort studies involving 6,217 controls and 693 cases. The pooled mean difference in serum 25(OH)D level between psoriatic patients and controls was -6.13 ng/ml (95% CI, -10.93 to -1.32, p-value = 0.01). The between-study heterogeneity (I2) was 98%, p < 0.00001.
CONCLUSION:
Our meta-analysis was the first study to establish the relation between vitamin D and psoriasis. The result found a significant relationship between low 25(OH) D levels and psoriasis, but did not establish a causal relationship. Further studies will be required to establish whether vitamin D supplementation benefits patients with psoriasis.