Vitamin D plasma concentrations in pregnant women and their preterm newborns.
BMC Pregnancy Childbirth. 2018 Oct 22;18(1):412. doi: 10.1186/s12884-018-2045-1.
Kassai MS1, Cafeo FR2, Affonso-Kaufman FA2, Suano-Souza FI3,4, Sarni ROS1.
- Preterm birth might be prevented by Vitamin D, Omega-3, etc. (International survey) – Jan 2019
- Preterm births 12 X more likely if poor Vitamin D Receptor (white infants in Italy) – meta-analysis Aug 2018
- Omega-3 index of 5 greatly decreases the risk of an early preterm birth – Dec 2018
- Preterm birth 4X more likely if Vitamin D deficient – Feb 2018
- Preterm births reduced by Vitamin D, Omega-3, Zinc – Oct 2019
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- Healthy pregnancies need lots of vitamin D
- Ensure a healthy pregnancy and baby - take Vitamin D before conception
Healthy pregnancies need lots of vitamin D has the following summary
ProblemReduces Evidence 0. Chance of not conceiving 3.4 times Observe 1. Miscarriage 2.5 times Observe 2. Pre-eclampsia 3.6 times RCT 3. Gestational Diabetes 3 times RCT 4. Good 2nd trimester sleep quality 3.5 times Observe 5. Premature birth 2 times RCT 6. C-section - unplanned 1.6 times Observe Stillbirth - OMEGA-3 4 times RCT - Omega-3 7. Depression AFTER pregnancy 1.4 times RCT 8. Small for Gestational Age 1.6 times meta-analysis 9. Infant height, weight, head size
within normal limitsRCT 10. Childhood Wheezing 1.3 times RCT 11. Additional child is Autistic 4 times Intervention 12.Young adult Multiple Sclerosis 1.9 times Observe 13. Preeclampsia in young adult 3.5 times RCT 14. Good motor skills @ age 3 1.4 times Observe 15. Childhood Mite allergy 5 times RCT 16. Childhood Respiratory Tract visits 2.5 times RCT RCT = Randomized Controlled Trial
Preterm births are VERY costly – Feb 2017 contains this cost-analysis
Assumptions: additional $50,000 per premature birth, $100 for education & supplements per pregnancyNet savings
per birth
After subtract
all costs# needed
to eliminate
1 pretermCost of
educ, supp
per pregnancyTotal cost
Educ/supp.Cost of
test per
pregnancyTotal
test
costsNet savings after
subtract costsVitamin D
(5,000 IU avg)$4,300 20 $100 $2,000 $200%%%(2 tests) $4,000 $43,000 Omega-3 $646 67 $100 $6,700 $0 $0 $43,300 Vitamin C
reduces early rupture$646 67 $100 $6,700 $0 $0 $43,300 Iodine $320 100 $100 $10,000 $80 $8,000 $32,000 Does not include additional savings to infant beyond the first year
such as reductions in Autism, MS, Respiratory Tract Infection, Asthma, Allergies
Does not include additional savings to mother
such as reduction in preeclampsia, miscarriage, gestational diabetes, depression
nor does it assign any costs for anguish of possible premie death, stillbirth, time off from work, job productivityDownload the PDF from Vitamin D Life
BACKGROUND:
Vitamin D deficiency is a global public health issue. More than half of pregnant women are affected by vitamin D insufficiency/deficiency. Studies suggest an association between low vitamin D concentrations during pregnancy with intrauterine growth restriction and prematurity. This study aimed to describe the concentrations of 25(OH)D (25-hydroxyvitamin D) of mothers who delivered preterm newborns compared to women with full-term pregnancy deliveries, as well as to relate 25(OH)D blood concentrations of mothers with those of their newborns.METHOD:
This cross-sectional study was conducted with 66 mothers who had given birth to preterm babies and their preterm newborns (PTNB, < 32 weeks), and 92 women who had given birth at the full-term of their pregnancy and their newborns (FTNB). Data were collected on the characteristics of mothers (gestational age, diseases, and habits) and newborns (anthropometry and adequacy for gestational age). Ten milliliters of blood were drawn from the mothers and the umbilical cord of newborns at birth to identify the 25(OH)D, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase concentrations.RESULTS:
Mothers in the PTNB group had significantly lower mean 25(OH)D blood levels (21.7 ± 10.8 ng/mL vs. 26.2 ± 9.8 ng/mL; p = 0.011) and were three times more likely to have insufficiency when compared to mothers in the FTNB group (OR = 2.993; 95%CI 1.02-8.74). Newborns in the PTNB group also had lower 25(OH)D concentrations compared to FTNB group (25.9 ± 13.9 ng/dL vs. 31.9 ± 12.3 ng/dL; p = 0.009). There was a directly proportional correlation between mother and newborn umbilical cord 25(OH)D concentrations in PTNB (r = 0.596; p < 0.001) and FTNB (r = 0.765; p < 0.001).CONCLUSION:
Mothers who delivered preterm babies and their preterm newborns had lower 25(OH)D concentrations compared to women who had given birth at the full-term of their pregnancy. In both groups, 25(OH)D concentrations of the mothers correlated directly with those of the newborns, and this correlation was higher in the full-term birth group. Nevertheless, the recommended universal vitamin D supplementation in pregnant women to curb the risk of preterm birth is still incipient. More studies are required to clarify the particularities of vitamin D metabolism further and define the adequate 25(OH)D concentrations throughout pregnancy.Preterm birth 3X more likely if low vitamin D – Oct 2018Printer Friendly PDF this page! Follow this page for updates850 visitors, last modified 26 Oct, 2019, This page is in the following categories (# of items in each category) - All items in category Infant/Child