Vitamin D and Insulin Action and Secretion –An Overview of Current Understanding and Future Perspectives
Birkeland Kare I, Gulseth Hanne L, Wium Cecilie
European Endocrinology, 2010;6(2):13–8
Impaired vitamin D status has been linked to the development of type 2 diabetes. This review summarises the current knowledge of the effects of vitamin D on insulin action and secretion. Animal and in vitro studies suggest an effect of vitamin D on insulin action and secretion. The effects of vitamin D status in humans are not as clear, however, and cross-sectional data on insulin sensitivity and secretion are inconclusive. Intervention studies are few and often suffer from inadequate design including short duration, low sample power, low dose of vitamin D or use of indirect measures of insulin sensitivity and secretion. Despite some plausible biological mechanisms for an effect of vitamin D on both insulin secretion and action, more evidence is needed to decide whether vitamin D plays an important role in the pathophysiology of type 2 diabetes.
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See also Vitamin D Life
- Overview of Diabetes and Vitamin D
- All articles on Diabetes and Vitamin D
- Can Vitamin D treat Diabetes
- 4000 IU vitamin D improved glycemic control for type 1 diabetes – Nov 2010
- Low vitamin D predicts all cause mortality in Type 2 Diabetes – Oct 2010
- Review of vitamin D deficiency and diabetes – Aug 2010
- Type 2 Diabetes and vitamin D – Aug 2010
- CDC confirms association between more vitamin D and less insulin – Jan 2011
- Vitamin D with or without Calcium helped glycemic status – Feb 2011