Association between non-melanoma and melanoma skin cancer rates, vitamin D and latitude
ONCOLOGY LETTERS 13: 3787-3792, 2017 DOI: 10.3892/ol.2017.5898
MIGUEL RIVAS1, ELISA ROJAS1, GLORIA M. CALAF2,3 gmc24 at columbia.edu, MARCELA BARBERAN4, CLAUDIO LIBERMAN4 and MARCELO DE PAULA CORREA5
1 2 Department of Physics, Faculty of Science; Institute for Advanced Research, Tarapaca University,Arica 8097877, 3 Chile; Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA; 4 Endocrinology and Diabetes Section, Clinical Hospital of University of Chile, Santiago 8320000, Chile; 5 Natural Resources Institute, Federal University of Itajuba, Itajuba, MG 37500-000, Brazil
- Overview Suntans melanoma and vitamin D
- Death from melanoma (without ulcers) greatly decreased if have lots of vitamin D receptors – May 2014
- UVA causes skin cancer, perhaps UVB (Vitamin D) prevents skin cancer – Jan 2017
- Melanoma REDUCED by those getting the most UV, unless 5 blistering sunburns while in teen years – June 2014
- Nonmelanoma skin cancer IS associated with increased risk of other cancers – March 2014 All associated with low vitamin D
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Melanoma
Non-melanoma
Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument. The results, which are presented in the current study, showed the association between NMSC and MSC rates, and the time required to produce 1,000 IU vitamin D with latitudinal variation. Solar UV index (UVI) levels reported in 6 cities from the north to the south of Chile indicated that the UVI ratio of monthly mean values was 1.8 times higher in Arica than in Punta Arenas in January (summer in Chile), whereas it was 14 times higher in June (winter). This factor is an important consideration, since vitamin D synthesis is directly associated with the exposure of individuals to solar UVB radiation. A similar trend was observed in Antofagasta, Santiago, Concepcion, Valdivia and Punta Arenas. It can be concluded from these data that there is a direct association between NMSC rates and mortality, and UVB radiation, meaning that this type of cancer would not depend on vitamin D synthesis and therefore on calcium uptake. By contrast, MSC rates increased with decreased levels of vitamin D, and thus calcium uptake, in all cities, with the only exception being Punta Arenas.