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MS assessment of role of vitamin D – July 2010

Assessment of evidence for a protective role of vitamin D in multiple sclerosis.

Biochim Biophys Acta. 2010 Jul 29. Epub ahead of print
Hanwell HE, Banwell B.
Department of Nutritional Sciences, University of Toronto and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada; Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Evidence for a role of vitamin D insufficiency in determining risk in Multiple Sclerosis (MS) is supported by studies in both pediatric- and adult-onset patients. The potential role of vitamin D in modulating MS disease activity is an area of active clinical trials research, and the possibility of primary disease prevention with vitamin D supplementation in early life is an emerging concept.

With Sir Austin Bradford Hill's criteria as a framework, the present review assesses the evidence for a causal relationship between vitamin D insufficiency and the pathobiology of MS, and discusses rationale for future clinical trials with vitamin D. Copyright © 2010. Published by Elsevier B.V. PMID: 20674744

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