Lew Body Dementia (Robin Williams) and low Vitamin D

See also Vitamin D Life

• Overview Cognition and vitamin D
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Robin's Wish - Movie Sept 2020

‘Robin’s Wish’ erases the sad clown trope around Robin Williams’s death
Includes link to the video trailer
"“He never got bitter,” Norwood continues. “He never got angry. Robin Williams wasn’t the guy who was going to go burn down the neighborhood the last night he was alive because he felt like things were unfair. He went and asked for a hug from one of his close friends. He said goodnight to his wife. And he realized that there just wasn’t much left on the earth for him. He was about two weeks from going into an inpatient program that he likely never would have come out of. And that’s just not how the guy wanted to live.”

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Lew Body dementia is associated with muscle spasms – low Magnesium/Vitamin D? - 2012

Dementia with Lewy bodies: the principles of diagnostics, treatment, and management.
Medicina (Kaunas). 2012;48(1):1-8.
Macijauskien? J, Lesauskait? V.
Department of Geriatrics, Medical Academy, Lithuanian University of Health Sciences, A. Mickevi?iaus 9, 44307 Kaunas, Lithuania. jurate.macijauskiene at lsmuni.lt

Dementia with Lewy bodies was first recognized as a separate entity about 30 years ago. The prevalence varies from 0% to 5% in the general population, and this disease accounts for 0% to 30.5% of all dementia cases.

Dementia with Lewy bodies is considered the second most common cause of degenerative dementia after Alzheimer's disease.

The disease is characterized by alpha-synuclein immunoreactive protein deposits in both neurons and glial cells. The protein deposits are especially prominent in dopaminergic neurons, where they can be detected using conventional histological stains, such as hematoxylin and eosin, and are commonly referred to as Lewy bodies.

The diagnosis of dementia with Lewy bodies is based on the presence of dementia as well as 2 of the following 3 core diagnostic features:

• 1) fluctuating cognition,
• 2) visual hallucinations, and
• 3) movement disorder.

Diagnostic tests include laboratory data, structural and functional imaging, and electroencephalography. Differential diagnosis of dementia with Lewy bodies focuses on other later life dementia syndromes, other parkinsonian diseases (Parkinson's disease, progressive supranuclear palsy, corticobasal degeneration), and primary psychiatric illnesses. There is type 1b evidence to support treatment with cholinesterase inhibitors. Glutamatergic and dopaminergic therapies are used as well. Standard neuroleptics are contraindicated, and atypical agents should be used cautiously. Nonpharmacologic measures - therapeutic environment, psychological and social support, physical activity, behavioral management strategies, caregivers' education and support, and different services - could be suggested.

PMID: 22481369
PDF is attached at the bottom of this page

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See also web

• “What is Lewy body dementia and how is it treated?” – UCSF webinar notes March 2020
  • "“Lewy body dementia” is an umbrella term that includes dementia with Lewy bodies and Parkinson’s disease dementia. The MAC has different webpages on these two disorders:..."
  • Many videos and descriptions
• A Form of Dementia That Is Often Misdiagnosed New York Times – Sept 2012
  • About 1.3 million Americans
  • Frequently misdiagnosed as Alzheimer’s or Parkinson’s disease
  • At a minimum, cognitive decline that doesn’t take the classic form of memory loss is a cue
  • Lewy body dementia seems to progress more rapidly than Alzheimer’s; most patients don’t live as long with it
• Wikipedia
• PubMed Lewy and Dementia in title 2147 items as of Sept 2020
• LBD Progression Nov 2019
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• LBD Venn - note the VDBP connection Dec 2015
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