Vitamin D supplementation, moderate sun exposure, and control of immune Diseases.
Hart PH.
Department of Inflammation, Telethon Institute for Child Health Research, University of Western Australia, Perth, Western Australia 6008, Australia.
Discov Med. 2012 Jun;13(73):397-404.
There is considerable debate about the benefits of vitamin D supplementation for multiple sclerosis, allergic asthma, and type 1 diabetes.
This has been driven mainly by observational studies linking vitamin D deficiency and insufficiency with increased prevalence of autoimmune and other diseases driven by immune processes.
Randomized controlled trials of vitamin D supplementation to treat these (and other) diseases have been disappointing.
This review examines the evidence that circulating vitamin D levels provide a surrogate measure of sun exposure and that it is the other molecules and pathways induced by sun exposure, rather than vitamin D-driven processes, that explain many of the benefits often attributed to vitamin D.
PMID: 22742645
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See also Vitamin D Life
- Less intestinal cancer in mice if add vitamin D, but even less with ultraviolet light – June 2014
- Solar UVB reduces Cancer Risk – Grant, Jan 2013
- Beneficial effects of UV radiation other than via vitamin D production – June 2012
- There is more in UV than vitamin D which suppresses MS in mice – April 2010
- Lack of UV 20X more associated with MS than any other variable – Dec 2010
- UV produces more than vitamin D – Aug 2011
- Opinion: sun better than UV better than vitamin D
- 5 Amazing Properties of Sunlight You've Never Heard About
- Hypothesis: Sun-produced nitric oxide reduces cardiovascular problems
- Benefits of sun are more than vitamin D – 2008
- UV decreases Multiple Sclerosis via cis-urocanic acid (and via vitamin D) – June 2013