Hydrogel encapsulation of vitamin D delays release in intestines – Sept 2018
Development of Hydrogels for Entrapment of Vitamin D3: Physicochemical Characterization and Release Study
Food Biophysics. Sept 2018, Vol 13, Issue 3, pp 284–291, DOI https://doi.org/10.1007/s11483-018-9534-7
Morteza Eslami Mohammad Shahed iMilad Fathi mfathi at cc.iut.ac.ir
Study does not appear to state when a delayed release is wanted
Perhaps want microbiome in colon to get more Vitamin D
Study does not compare the use of hydrogels to various emulsions
Release time in acidic environment
| 50% of stomach contents emptied | 2.5 to 3 hours |
| Total emptying of the stomach | 4 to 5 hours |
| 50% emptying of the small intestine | 2.5 to 3 hours |
| Transit through the colon | 30 to 40 hours |
Vitamin D Life comment
Perhaps the delayed release provides more vitamin D to the large intestine (treat/prevent colon cancer) as well as benefit the gut bacteria
PDF is available free at Sci-Hub 10.1007/s11483-018-9534-7
In this study two carbohydrate biopolymers were used to entrap vitamin D3. In order to optimize the microencapsulation parameters, response surface methodology was applied to evaluate the effects of three independent variables (alginate percentage, vitamin: alginate weight ratio, and ultrasound time) on the efficiency of microencapsulation and loading capacity. According to the results, 0.23% alginate (W/V), 1: 5 weight ratio of vitamin D3: alginate, and 13.7 min ultrasound time were determined as the optimal conditions for obtaining maximum microencapsulation efficiency (92.86%) and loading capacity (30.1%). Then, the optimized carrier was coated by chitosan followed by the examinations of morphological characteristics, mean particle size, Fourier transform infrared (FTIR) spectrometry, in vitro release characteristics, and release modeling. Scanning electron microscopy examinations showed that the alginate and alginate-chitosan microcapsules had irregular and interlacing forms. The average particle sizes of alginate and alginate-chitosan were 11.3 and 23.3, respectively, which decreased to 9.8 and 14.0 μm after drying. Results of FTIR indicated a physical interaction between alginate and vitamin D3. The Weibull II model was found to be the best one to predict vitamin release behavior. The results of this study showed the potential application of developed carriers to encapsulate hydrophobic compounds.
See Vitamin D Life on new forms of Vitamin D
Breathing/Lungs
- Inhaled nanoemulsion of Vitamin D killed lung bacteria – Sept 2017
- The lungs can activate vitamin D locally – a Vitamin D inhaler may help lungs – Aug 2016
Cancer
- Liposomal Vitamin D cocktail targets some lung cancers – June 2018
- Active vitamin D appears to treat cancer – more studies needed – June 2018
Gut Microbionome
- Gut microbiome massively changed by high dose vitamin D – July 2015
- Gut bacteria of Crohn's disease patients improved by Vitamin D – March 2018
- Vitamin D Receptor in gut can be activated by lithocholic acid produced by gut bacteria
- Probiotic and vitamin D synergy - July 2015
- Vitamin D, immunity and microbiome – Dec 2014
There have actually been
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